Evidence map›Paper›PMID 34272971›Full record

ReviewArchives of dermatological research2022

Cutaneous soft tissue sarcomas: survival-related factors.

Areti Gkantaifi, Alexandros Diamantis, Davide Mauri, Ioanna Nixon, Anastassios Kyriazoglou, Ioannis Baloyiannis, Nikolaos Tsoukalas, Nikolaos Charalampakis, Dimitrios Schizas, Francesco Cuccia and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of dermatological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 5 countries.

Areti Gkantaifi *Radiotherapy Department, Theagenio Anticancer Hospital of Thessaloniki, Thessaloniki, Greece.
Alexandros Diamantis *Department of General Surgery, University Hospital of Larisa, Biopolis, 415 00, Larisa, Thessaly, Greece.
Davide MauriDepartment of Medical Oncology, University Hospital of Ioannina, Ioannina, Greece.
Ioanna NixonBeatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 0YN, UK.
Anastassios Kyriazoglou2nd Propaedeutic Department of Medicine, Attikon University Hospital, Rimini St, Chaidari, 124 62, Athens, Greece.
Ioannis BaloyiannisDepartment of General Surgery, University Hospital of Larisa, Biopolis, 415 00, Larisa, Thessaly, Greece.
Nikolaos TsoukalasOncology Clinic, 401 General Military Hospital, 115 25, Athens, Greece.
Nikolaos CharalampakisOncology Clinic, Metaxa Cancer Hospital, Mpotasi 51, 185 37, Piraeus, Greece.
Dimitrios SchizasFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Francesco CucciaAdvanced Radiation Oncology Department, IRCCS SacroCuore Don Calabria, Negrar, Verona, Italy.
Filippo AlongiAdvanced Radiation Oncology Department, IRCCS SacroCuore Don Calabria, Negrar, Verona, Italy.
Ramon Andrade de MelloPrecision Oncology and Health Economics Research Group, Division of Medical Oncology, Federal University of São Paulo (UNIFESP) and Post Graduation Program in Medicine, Nine of July University (UNINOVE), São Paulo, Brazil.
George IliadisRadiotherapy Department, Interbalkan Medical Center, Thessaloniki, Greece.
Konstantinos KamposiorasDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
Michalis MazonakisDepartment of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, 710 03, Iraklion, Crete, Greece.
Maria ToliaDepartment of Radiotherapy, University Hospital/Medical School, University of Crete, Vassilika, 711 10, Crete, Greece. mariatolia@uoc.gr.ORCID http://orcid.org/0000-0001-5822-4363
Ospedale Sacro Cuore Don Calabria · ITUniversity of Crete · GR401 General Military Hospital of Athens · GRBeatson West of Scotland Cancer Centre · GBInterbalkan Medical Center · GRMetaxa Hospital · GRNational and Kapodistrian University of Athens · GRTheageneio General Hospital · GRThe Christie NHS Foundation Trust · GBUniversidade Nove de Julho · BRUniversity General Hospital Attikon · GRUniversity Hospital of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous sarcomas are a heterogeneous group of rare mesenchymal neoplasms representing less than 1% of malignant tumors. Histology report remains the cornerstone for the diagnosis of these tumors. The most important clinicopathologic parameters related to prognosis include larger tumor size, high mitotic index, head and neck location, p53 mutations, depth of infiltration and histological grade, vascular and perineural invasion as well as the surgical margins status. Applying advanced biopsy techniques might offer more precise assessment of surgical margins, which constitutes a significant precondition for the management of these tumors. The management of cutaneous soft tissue sarcomas requires a multidisciplinary approach. Surgery remains the standard treatment, nonetheless adjuvant therapy may be required, consisting of radiotherapy, chemotherapy, and molecular targeted therapies to improve treatment outcomes. The role of molecular profiling in the treatment of uncontrolled disease is promising, but it may be offered to a relatively small proportion of patients and its use is still considered experimental in this setting. Due to the rarity of the disease, there is a need for knowledge and experience to be shared, pooled, organized and rationalized so that recent developments in medical science can have a major impact on the disease course. Multicenter clinical trials are needed to improve the care of patients with cutaneous sarcomas.

Indexed as

SarcomaSkin NeoplasmsSoft Tissue NeoplasmsCombined Modality TherapyHumansMargins of ExcisionMulticenter Studies as TopicPrognosisBiopsyCutaneousFactorsRecurrenceSarcomasSurvivalTreatment

Identifiers

PMID34272971
OpenAlexW3179136741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.