Evidence map›Paper›PMID 34272767›Full record

ArticleMagnetic resonance in medicine2021

Noninvasive assessment of steatosis and viability of cold-stored human liver grafts by MRI.

Liam A J Young, Carlo D L Ceresa, Ferenc E Mózes, Jane Ellis, Ladislav Valkovič, Richard Colling, Constantin-C Coussios, Peter J Friend, Christopher T Rodgers

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Liam A J YoungOxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-0720-421X
Carlo D L CeresaNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Ferenc E MózesOxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jane EllisOxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Ladislav ValkovičOxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2567-3642
Richard CollingNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Constantin-C CoussiosInstitute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom.
Peter J FriendNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Christopher T RodgersOxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1275-1197
John Radcliffe Hospital · GBNuffield Orthopaedic Centre · GBSlovak Academy of Sciences · SKUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

Wellcome Trust 098436Wellcome Trust 098436/Z/12/BWellcome Trust 221805Wellcome Trust 221805/Z/20/Z
6 · The paper itself

Abstract

purposeA shortage of suitable donor livers is driving increased use of higher risk livers for transplantation. However, current biomarkers are not sensitive and specific enough to predict posttransplant liver function. This is limiting the expansion of the donor pool. Therefore, better noninvasive tests are required to determine which livers will function following implantation and hence can be safely transplanted. This study assesses the temperature sensitivity of proton density fat fraction and relaxometry parameters and examines their potential for assessment of liver function ex vivo.

methodsSix ex vivo human livers were scanned during static cold storage following normothermic machine perfusion. Proton density fat fraction, T

resultsStrong linear temperature sensitivities were observed for proton density fat fraction (R

conclusionTemperature correction is essential for robust measurement of proton density fat fraction and T

Indexed as

Fatty LiverLiver TransplantationHumansLiverMagnetic Resonance ImagingPerfusionliver transplantationMOLLI T1normothermic machine perfusionproton density fat fractionstatic cold storagetemperature sensitivity

Identifiers

PMID34272767
PMCPMC7613197
OpenAlexW3179260922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.