Evidence map›Paper›PMID 34272765›Full record

ArticleJournal of clinical laboratory analysis2021

Association of DYNC1H1 gene SNP/CNV with disease susceptibility, GCs efficacy, HRQOL, anxiety, and depression in Chinese SLE patients.

Shunwei Huang, Tingyu Zhang, Yuhua Wang, Linlin Wang, Ziye Yan, Ying Teng, Zhen Li, Qiuyue Lou, Shuang Liu, Jing Cai and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Analysis of theGenes · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Shunwei HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0003-2566-5976
Tingyu ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Yuhua WangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Linlin WangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Ziye YanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Ying TengDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Zhen LiDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Qiuyue LouDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Shuang LiuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jing CaiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yangfan ChenDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Mu LiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hailiang HuangDepartment of Laboratory Medicine, School of Public Health, Anhui Medical University, Hefei, China.
Zhouzhou XuDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Yanfeng ZouDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.ORCID https://orcid.org/0000-0002-2327-6718
Anhui Medical University · CN

Funding

National Natural Science Foundation of China 81673254National Natural Science Foundation of China 81872683
6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus is a heterogeneous autoimmune disease characterized by multi-system injuries and overproduction of autoantibodies. There are many genetic studies on SLE, but no report has considered the relationship between cytoplasmic dynein and SLE susceptibility.

objectivesOur study intends to investigate whether DYNC1H1 gene SNP/CNV is related to SLE susceptibility, GCs efficacy, HRQOL, anxiety, and depression in Chinese SLE patients.

methodsA total of 502 cases and 544 healthy controls were recruited into the case-control study, and 472 subjects from the case group were followed up for 12 weeks to evaluate GCs efficacy, HRQOL, anxiety, and depression. Multiplex SNaPshot technique was applied to genotype the seven SNPs of DYNC1H1, and AccuCopy

resultsThe significant association between SNP rs1190606 and SLE susceptibility was displayed in the dominant model (P

conclusionsThe study suggests that DYNC1H1 gene polymorphisms may have an effect on SLE susceptibility and BP improvement of HRQOL in Chinese SLE patients.

Indexed as

AdultAnxietyAsian PeopleCase-Control StudiesCytoplasmic DyneinsDepressionDNA Copy Number VariationsFemaleGene FrequencyGenetic Predisposition to DiseaseGlucocorticoidsHaplotypesHumansLupus Erythematosus, SystemicMalePolymorphism, Single NucleotideCytoplasmic DyneinsDYNC1H1 protein, humanGlucocorticoidscopy number variationglucocorticoidssingle nucleotide polymorphismsystemic lupus erythematosus

Identifiers

PMID34272765
PMCPMC8373356
OpenAlexW3179445199

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.