Evidence map›Paper›PMID 34272637›Full record

ArticleMolecular diversity2021

Identification of kinase inhibitors that rule out the CYP27B1-mediated activation of vitamin D: an integrated machine learning and structure-based drug designing approach.

Kanupriya Mahajan, Himanshu Verma, Shalki Choudhary, Baddipadige Raju, Om Silakari

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kanupriya MahajanMolecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, 147002, India.
Himanshu VermaMolecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, 147002, India.
Shalki ChoudharyMolecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, 147002, India.
Baddipadige RajuMolecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, 147002, India.
Om SilakariMolecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, 147002, India. omsilakari@gmail.com.ORCID https://orcid.org/0000-0002-1174-1125
Punjabi University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1α,25(OH)

Indexed as

Machine LearningModels, Molecular25-Hydroxyvitamin D3 1-alpha-HydroxylaseAlgorithmsAmino Acid SequenceAnimalsBinding SitesDatabases, PharmaceuticalDrug DesignEnzyme InhibitorsHumansMetabolic Networks and PathwaysMolecular Docking SimulationMolecular Dynamics SimulationNeural Networks, ComputerPhosphotransferases25-Hydroxyvitamin D3 1-alpha-HydroxylaseEnzyme InhibitorsPhosphotransferasesSmall Molecule LibrariesVitamin DBindingDBCYP27B1Kinase inhibitorsMachine learningVitamin D

Identifiers

PMID34272637
OpenAlexW3182439911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.