Evidence map›Paper›PMID 34272624›Full record

ReviewCurrent oncology reports2021

Current Understanding and Management of Intraductal Carcinoma of the Prostate.

Bryden Considine, Adebowale Adeniran, Michael E Hurwitz

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bryden ConsidineYale Comprehensive Cancer Center, 333 Cedar St, New Haven, CT, 06510, USA.
Adebowale AdeniranYale Comprehensive Cancer Center, 333 Cedar St, New Haven, CT, 06510, USA.
Michael E HurwitzYale Comprehensive Cancer Center, 333 Cedar St, New Haven, CT, 06510, USA. michael.hurwitz@yale.edu.ORCID 0000-0002-1326-7308
Yale Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review will discuss current understanding and management approaches of Intraductal carcinoma of the prostate (IDC-P). IDC-P is a histological finding characterized by neoplastic cells that expand but do not invade prostate ducts. RECENT

findingsThe presence of IDC-P on a prostate biopsy is almost always associated with an invasive disease component and is independently associated with worse clinical outcomes in both early and late disease. These tumors are enriched for mutations in homologous DNA recombination repair (HRR) leading to high genomic instability. Multiparametric MRI with targeted biopsy may aid in diagnosis. Given the poor clinical outcomes associated with this histologic entity, its presence in biopsies should warrant consideration of aggressive management.

Indexed as

Microsatellite InstabilityMutationCarcinoma, DuctalDNA Mismatch RepairGenetic Predisposition to DiseaseHumansMaleNeoplasm GradingProstatic NeoplasmsSignal TransductionAcinarCribriformDuctalHGPINIntraductalMultiparametric MRIProstate

Identifiers

PMID34272624
OpenAlexW3179877143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.