Evidence map›Paper›PMID 34272618›Full record

ReviewCell biology and toxicology2021

RNA methylation in mammalian development and cancer.

Peizhe Song, Subiding Tayier, Zhihe Cai, Guifang Jia

Open access · hybridAbstract readReview
In one paragraph

Review in Cell biology and toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 128 citations in OpenAlex.

  1. RNA regulation in plants.Science China. Life sciences · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Epigenetic Effects and Potential Contributions of mAnimals : an open access journal from MDPI · 2025
    Article
  8. Article
  9. Article
  10. Hsa_circ_0101308 adjusted by N6-methyladenosine (mCancer biomarkers : section A of Disease markers · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Mettl1-mediated mInternational journal of biological sciences · 2025
    Article
  17. Review
  18. Review
  19. Review
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peizhe Song *Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Subiding Tayier *Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Zhihe CaiSynthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Guifang JiaSynthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. guifangjia@pku.edu.cn.
Beijing National Laboratory for Molecular Sciences · CNPeking University · CN

Funding

National Basic Research Program of China (973 Program) 2017YFA0505201National Basic Research Program of China (973 Program) 2019YFA0802201National Natural Science Foundation of China 21432002National Natural Science Foundation of China 21820102008National Natural Science Foundation of China 21822702National Natural Science Foundation of China 92053109
6 · The paper itself

Abstract

Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA modifications) have emerged as crucial regulators in temporal and spatial gene expression during eukaryotic development. To date, over 170 diverse types of chemical modifications have been identified upon RNA nucleobases. Some of these post-synthesized modifications can be reversibly installed, removed, and decoded by their specific cellular components and play critical roles in different biological processes. Accordingly, dysregulation of RNA modification effectors is tightly orchestrated with developmental processes. Here, we particularly focus on three well-studied RNA modifications, including N

Indexed as

AdenosineNeoplasmsAnimalsCell DifferentiationMethylationRNAAdenosineRNA5-methylcytosineCancer progressionEmbryonic developmentN 1-methyladenosineN 6-methyladenosineRNA metabolismStem cell fate determination

Identifiers

PMID34272618
PMCPMC8599391
OpenAlexW3182626601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.