Evidence map›Paper›PMID 34272581›Full record

ArticleDiabetologia2021

Local islet remodelling associated with duct lesion-islet complex in adult human pancreas.

Yu-Wen Tien, Hung-Jen Chien, Tsai-Chen Chiang, Mei-Hsin Chung, Chih-Yuan Lee, Shih-Jung Peng, Chien-Chia Chen, Ya-Hsien Chou, Fu-Ting Hsiao, Yung-Ming Jeng and 1 more

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Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yu-Wen TienDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Hung-Jen ChienInstitute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Tsai-Chen ChiangDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Mei-Hsin ChungInstitute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Chih-Yuan LeeDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Shih-Jung PengDepartment of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
Chien-Chia ChenDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Ya-Hsien ChouInstitute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Fu-Ting HsiaoInstitute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Yung-Ming JengDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Shiue-Cheng TangInstitute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. sctang@life.nthu.edu.tw.ORCID 0000-0002-9384-1663
National Tsing Hua University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisIslets are thought to be stably present in the adult human pancreas to maintain glucose homeostasis. However, identification of the pancreatic intraepithelial neoplasia (PanIN)-islet complex in mice and the presence of PanIN lesions in adult humans suggest that similar remodelling of islet structure and environment may occur in the human pancreas. To identify islet remodelling in a clinically related setting, we examine human donor pancreases with 3D histology to detect and characterise the human PanIN-islet complex.

methodsCadaveric donor pancreases (26-65 years old, n = 10) were fixed and sectioned (350 μm) for tissue labelling, clearing and microscopy to detect local islet remodelling for 3D analysis of the microenvironment. The remodelled microenvironment was subsequently examined via microtome-based histology for clinical assessment.

resultsIn nine pancreases, we identified the unique peri-lobular islet aggregation associated with the PanIN lesion (16 lesion-islet complexes detected; size: 3.18 ± 1.34 mm). Important features of the lesion-islet microenvironment include: (1) formation of intra-islet ducts, (2) acinar atrophy, (3) adipocyte association, (4) inflammation (CD45 CONCLUSIONS/

interpretationWe identify local islet remodelling associated with PanIN-islet complex in the adult human pancreas. The tissue remodelling and the evidence of inflammation and stromal accumulation suggest that the PanIN-islet complex is derived from tissue repair after a local injury.

Indexed as

ActinsAdipocytesAdultAgedCell ProliferationCellular MicroenvironmentFemaleHumansImaging, Three-DimensionalIslets of LangerhansKi-67 AntigenLeukocyte Common AntigensMaleMicroscopy, ConfocalMiddle AgedPancreatic DuctsActinsKi-67 AntigenLeukocyte Common AntigensPECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1PTPRC protein, human3D pancreatic histologyHuman isletIntra-islet ductIslet aggregationIslet cell neogenesisPancreatic intraepithelial neoplasia

Identifiers

PMID34272581
OpenAlexW3182149925

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.