Evidence map›Paper›PMID 34272524›Full record

ArticleNature biomedical engineering2021

Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays.

Chonghe Wang, Baiyan Qi, Muyang Lin, Zhuorui Zhang, Mitsutoshi Makihata, Boyu Liu, Sai Zhou, Yi-Hsi Huang, Hongjie Hu, Yue Gu and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. MUSiK: An Open Source Simulation Library for 3D Multi-View Ultrasound.IEEE transactions on bio-medical engineering · 2026
    Article
  14. Article
  15. Review
  16. Curvy Surface Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  17. Review
  18. Review
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chonghe Wang *Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Baiyan Qi *Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA, USA.
Muyang Lin *Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6627-6294
Zhuorui Zhang *Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Mitsutoshi MakihataDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Boyu LiuDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Sai ZhouDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Yi-Hsi HuangDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Hongjie HuMaterials Science and Engineering Program, University of California, San Diego, La Jolla, CA, USA.
Yue GuMaterials Science and Engineering Program, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0437-5339
Yimu ChenDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Yusheng LeiDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA.
Taeyoon LeeSchool of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea.
Shu ChienDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Kyung-In JangDepartment of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
Erik B KistlerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Sheng XuDepartment of Nanoengineering, University of California, San Diego, La Jolla, CA, USA. shengxu@ucsd.edu.ORCID http://orcid.org/0000-0002-3120-4992

Funding

Recording central blood flow velocity waveform by conformal ultrasonic devicesR21EB027303 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI XU, SHENG · 2019 to 2022
$775k
NIBIB NIH HHS R21 EB027303
6 · The paper itself

Abstract

Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14 cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.

Indexed as

Cerebrovascular CirculationHeartHemodynamicsHumansMicroarray AnalysisMonitoring, PhysiologicSignal-To-Noise RatioUltrasonography, DopplerWearable Electronic Devices

Identifiers

PMID34272524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.