SynthesisEye (London, England)2022
Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.
Synthesis in Eye (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- A meta-analytical umbrella review assessing urban environment exposures and cognitive health outcomes.Age and ageing · 2026Pooled it
- Community-based interventions to detect visual impairment in community-dwelling older adults aged ≥ 75 years: a systematic review.BMC public health · 2025Pooled it
- Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses.BMC endocrine disorders · 2022Pooled it
- An eyecare foundation model for clinical assistance: a randomized controlled trial.Nature medicine · 2025Trial
- Experiences and perceptions of unrecognised vision loss in the lives of community-dwelling older adults in Denmark: a qualitative study.BMC geriatrics · 2026Article
- A Lightweight CNN for Multiclass Retinal Disease Screening with Explainable AI.Journal of imaging · 2025Article
- Mortality and ocular parameters and diseases.Eye (London, England) · 2025Article
- The novel antidiabetic medications on diabetic retinopathy: relevant molecular mechanisms, advancing diagnostic innovations, and therapeutic implications.Frontiers in medicine · 2025Review
- The burden, causes, and determinants of blindness and vision impairment in Asia: An analysis of the Global Burden of Disease Study.Journal of global health · 2024Article
- Association of diabetic retinopathy on all-cause and cause-specific mortality in older adults with diabetes: National Health and Nutrition Examination Survey, 2005-2008.Scientific reports · 2024Article
- Susceptibility to eye diseases in relation to age and kidney failure among Taiwanese adults.BMC geriatrics · 2024Article
- The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine.The EPMA journal · 2023Article
- Awareness of Common Eye Diseases and Their Risk Factors-A Nationwide Cross-Sectional Survey among Adults in Poland.International journal of environmental research and public health · 2023Article
- Eye Care Behaviors among Adults in Poland: A Nationwide Cross-Sectional Survey.International journal of environmental research and public health · 2023Article
- Current approaches to vision restoration using optogenetic therapy.Frontiers in cellular neuroscience · 2023Review
- Perioperative Ischemic Optic Neuropathy after Cardiac Surgery: Development and Validation of a Preoperative Risk Prediction Model.Journal of cardiothoracic and vascular anesthesia · 2022Article
- Temporal trajectories of important diseases in the life course and premature mortality in the UK Biobank.BMC medicine · 2022Article
- Virtual reality training improves accommodative facility and accommodative range.International journal of ophthalmology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, 2.2 billion people live with some form of vision impairment and/or eye disease. To date, most systematic reviews examining associations have focused on a single eye disease and there is no systematic evaluation of the relationships between eye diseases and diverse physical and mental health outcomes. Moreover, the strength and reliability of the literature is unclear. We performed an umbrella review of observational studies with meta analyses for any physical and/or mental comorbidities associated with eye disease. For each association, random-effects summary effect size, heterogeneity, small-study effect, excess significance bias and 95% prediction intervals were calculated, and used to grade significant evidence from convincing to weak. 34 studies were included covering 58 outcomes. No outcomes yielded convincing evidence, six outcomes yielded highly suggestive results (cataract positively associated with type 2 diabetes, open-angled glaucoma positively associated with myopia and diabetes, diabetic retinopathy positively associated with cardiovascular disease and cardiovascular mortality, and retinopathy of prematurity positively associated with chorioamnionitis), eight outcomes yielded suggestive results (diabetic retinopathy positively associated with all-cause mortality and depression, diabetic macular oedema positively associated with dyslipidaemia, cataract positively associated with gout, nuclear sclerosis positively associated with all-cause mortality, open angled glaucoma positively associated with migraine and hypertension, and age-related macular degeneration positively associated with diabetes), and 18 outcomes yielded weak evidence. Results show highly suggestive or suggestive evidence for associations between several types of eye diseases with several comorbid outcomes. Practitioners and public health policies should note these findings when developing healthcare policies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.