ArticleScientific reports2021
3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Reconfigurable multibeam engineering of Marangoni convection for programmable optofluidic steering.Nature communications · 2026Article
- 3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.bioRxiv : the preprint server for biology · 2025Article
- A Review on 3D-Printed Miniaturized Devices for Point-of-Care-Testing Applications.Biosensors · 2025Review
- 3D Printed Microfluidic Devices for Integrated Immunoaffinity Extraction, Solid-Phase Extraction, and Fluorescent Labeling of Preterm Birth Biomarkers.Precision chemistry · 2025Article
- 3D printed electrode-microwell system: a novel electrochemical platform for miRNA detection.Mikrochimica acta · 2025Article
- 3D bioprinting of collagen-based high-resolution internally perfusable scaffolds for engineering fully biologic tissue systems.Science advances · 2025Article
- Development of Hydrogels Fabricated via Stereolithography for Bioengineering Applications.Polymers · 2025Review
- Lab-on-a-chip models of cardiac inflammation.Biomicrofluidics · 2024Review
- Lab-on-a-chip: an advanced technology for the modernization of traditional Chinese medicine.Chinese medicine · 2024Review
- Unpacking the packaged optical fiber bio-sensors: understanding the obstacle for biomedical application.Frontiers in bioengineering and biotechnology · 2024Review
- 3D bio-printed hydrogel inks promoting lung cancer cell growth in a lab-on-chip culturing platform.Mikrochimica acta · 2023Article
- Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review.Micromachines · 2023Review
- Optimization of 3D printing andFrontiers in bioengineering and biotechnology · 2023Article
- Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices.Frontiers in bioengineering and biotechnology · 2023Review
- A Novel Methodology for Detecting Variations in Cell Surface Antigens Using Cell-Tearing by Optical Tweezers.Biosensors · 2022Article
- Recent progress of microfluidic chips in immunoassay.Frontiers in bioengineering and biotechnology · 2022Review
- 3D Printed Microfluidic Spiral Separation Device for Continuous, Pulsation-Free and Controllable CHO Cell Retention.Micromachines · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples. A square zig-zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.