Evidence map›Paper›PMID 34272322›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Safety of PSMA-Targeted Molecular Radioligand Therapy with

Jeremie Calais, Johannes Czernin, Pan Thin, Jeannine Gartmann, Kathleen Nguyen, Wesley R Armstrong, Martin Allen-Auerbach, Andrew Quon, Shadfar Bahri, Pawan Gupta and 9 more

Open access · bronzeAbstract readMulticenter StudyClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Joint EANM/SNMMI procedure guideline for the use ofEuropean journal of nuclear medicine and molecular imaging · 2023
    Guideline
  2. Tumor and Organ Dose Estimates fromJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  3. Review
  4. Article
  5. Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Hematological toxicity of [EJNMMI radiopharmacy and chemistry · 2025
    Article
  10. Efficacy ofBiomedicines · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Best Patient Care Practices for Administering PSMA-Targeted Radiopharmaceutical Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Review
  15. Impact of Posttreatment SPECT/CT on Patient Management DuringJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  16. Prostate-Specific Membrane Antigen-Targeted Imaging and Its Correlation with HOXB13 Expression.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  17. Article
  18. Differences and Common Ground inJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Jeremie Calais
Johannes Czernin
Pan ThinAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Jeannine GartmannAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Kathleen NguyenAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Wesley R ArmstrongAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Martin Allen-Auerbach
Andrew Quon
Shadfar Bahri
Pawan GuptaAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Linda GardnerAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Magnus DahlbomAhmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, California.
Beilei HeAdvanced Accelerator Applications, a Novartis Company, Geneva, Switzerland.
Rouzbeh EsfandiariExcel Diagnostics and Nuclear Oncology Center, Houston, Texas.
David RanganathanRadioMedix, Inc., Houston, Texas.
Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and.
Matthias EiberDepartment of Nuclear Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany.
Wolfgang P FendlerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and.
Ebrahim DelpassandExcel Diagnostics and Nuclear Oncology Center, Houston, Texas.
University of California, Los Angeles · USMolecular Theranostics (United States) · USEssen University Hospital · DERadioMedix (United States) · USExcel Diagnostics Imaging · USKlinikum rechts der Isar · DENovartis (Switzerland) · CH

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

The purpose of this analysis was to report the safety evaluation of

Indexed as

DipeptidesGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingLutetiumProstatic Neoplasms, Castration-ResistantAgedAged, 80 and overAntigens, SurfaceHumansLigandsMaleMiddle AgedMolecular Targeted TherapyProspective StudiesProstate-Specific AntigenRadiopharmaceuticalsAntigens, SurfaceDipeptidesFOLH1 protein, humanGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingLigandsLutetiumPluvictoProstate-Specific AntigenRadiopharmaceuticals177Lumetastatic castration-resistant prostate cancermolecular radiotherapyprospective randomized phase 2 trialprostate-specific membrane antigenradionuclide therapyRESIST-PCsafetytheranostics

Identifiers

PMID34272322
PMCPMC8724902
OpenAlexW3180086826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.