Evidence map›Paper›PMID 34272309›Full record

ReviewJournal for immunotherapy of cancer2021

Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors.

Benjamin Switzer, John Haanen, Paul C Lorigan, Igor Puzanov, Samra Turajlic

Abstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Immune checkpoint inhibitor-associated myocarditis: clinical and mechanistic insights.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin SwitzerDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID 0000-0001-8150-1963
John HaanenDivision of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Paul C LoriganDivision of Cancer Sciences, The University of Manchester, Manchester, UK.
Igor Puzanov *Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA igor.puzanov@roswellpark.org samra.turajlic@crick.ac.uk.
Samra Turajlic *Renal and Skin Units, Royal Marsden NHS Foundation Trust, London, UK igor.puzanov@roswellpark.org samra.turajlic@crick.ac.uk.

Funding

Deciphering Clonal Evolution in Hereditary Renal Cell CarcinomasU01CA247439 · NCI · FRANCIS CRICK INSTITUTE, LTD · PI TURAJLIC, SAMRA · 2020 to 2024
$1.1M
Cancer Research UK 29911NCI NIH HHS U01 CA247439Wellcome Trust
6 · The paper itself

Abstract

The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer receiving systemic anticancer therapy have introduced a multitude of clinical challenges and academic controversies. This review summarizes the current evidence, discussion points, and recommendations regarding the use of immune checkpoint inhibitors (ICIs) in patients with cancer during the SARS-CoV-2 pandemic, with a focus on patients with melanoma and renal cell carcinoma (RCC). More specifically, we summarize the theoretical concepts and available objective data regarding the relationships between ICIs and the antiviral immune response, along with recommended clinical approaches to the management of melanoma and RCC patient cohorts receiving ICIs throughout the course of the COVID-19 pandemic. Additional insights regarding the use of ICIs in the setting of current and upcoming COVID-19 vaccines and broader implications toward future pandemics are also discussed.

Indexed as

Carcinoma, Renal CellCOVID-19COVID-19 Drug TreatmentCOVID-19 VaccinesHumansImmune Checkpoint InhibitorsImmunotherapyKidney NeoplasmsMelanomaPandemicsSARS-CoV-2COVID-19 VaccinesImmune Checkpoint InhibitorsCOVID-19immunotherapykidney neoplasmsmelanomavaccination

Identifiers

PMID34272309
PMCPMC8288220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.