Evidence map›Paper›PMID 34272290›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Sorting of cadherin-catenin-associated proteins into individual clusters.

Regina B Troyanovsky, Alina P Sergeeva, Indrajyoti Indra, Chi-Shuo Chen, Rei Kato, Lawrence Shapiro, Barry Honig, Sergey M Troyanovsky

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions.Advances in experimental medicine and biology · 2026
    Review
  7. E-Cadherin: A conductor of cellular signaling.Current opinion in cell biology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Characterization of early and late events of adherens junction assembly.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Regina B TroyanovskyDepartment of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Alina P SergeevaDepartment of Systems Biology, Columbia University Medical Center, New York, NY 10032.ORCID 0000-0002-8886-4123
Indrajyoti IndraDepartment of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0001-5381-7397
Chi-Shuo ChenDepartment of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Rei KatoDepartment of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Barry HonigDepartment of Systems Biology, Columbia University Medical Center, New York, NY 10032; bh6@columbia.edu s-troyanovsky@northwestern.edu.
Sergey M TroyanovskyDepartment of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; bh6@columbia.edu s-troyanovsky@northwestern.edu.
Northwestern University · USColumbia University Irving Medical Center · USColumbia University · US

Funding

Inter-junctional signaling in epithelial junctional complexR01AR044016 · NIAMS · WASHINGTON UNIVERSITY · PI TROYANOVSKY, SERGEY M · 1996 to 2020
$6.8M
The structural basis of cis and trans protocadherin interactionsR01MH114817 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2017 to 2021
$2.4M
Structure and Function of Desmosomal CadherinsR01GM118584 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAPIRO, LAWRENCE S · 2017 to 2020
$1.8M
Functional and Structural Links between Cadherin, Gamma-Secretase, and NotchR01AR057992 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TROYANOVSKY, SERGEY M · 2010 to 2014
$1.6M
Inter-junctional signaling in epithelial junctional complexR56AR044016 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TROYANOVSKY, SERGEY M · 2015 to 2015
$435k
NIAMS NIH HHS R01 AR044016NIAMS NIH HHS R01 AR057992NIAMS NIH HHS R56 AR044016NIGMS NIH HHS R01 GM118584NIMH NIH HHS R01 MH114817
6 · The paper itself

Abstract

The cytoplasmic tails of classical cadherins form a multiprotein cadherin-catenin complex (CCC) that constitutes the major structural unit of adherens junctions (AJs). The CCC in AJs forms junctional clusters, "E clusters," driven by

Indexed as

ActinsAdaptor Proteins, Signal TransducingAdherens JunctionsAntibodies, MonoclonalCadherinsCateninsCell AdhesionCell LineGreen Fluorescent ProteinsHumansMembrane ProteinsModels, MolecularMutationProtein BindingProtein TransportTumor Suppressor ProteinsActinsAdaptor Proteins, Signal TransducingAntibodies, MonoclonalCadherinsCateninsERBIN protein, humanGreen Fluorescent ProteinsMembrane ProteinsSCRIB protein, humanTumor Suppressor Proteinsadherens junctionscadherincadherin-associated proteinscateninsprotein sorting

Identifiers

PMID34272290
PMCPMC8307379
OpenAlexW3180149529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.