ArticleProceedings of the National Academy of Sciences of the United States of America2021
Altered sense of self during seizures in the posteromedial cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Neural bases of the bodily self as revealed by electrical brain stimulation: A systematic review.Human brain mapping · 2023Pooled it
- Ketamine reduces the neural distinction between self- and other-produced affective touch: a randomized double-blind placebo-controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.Journal of neurophysiology · 2026Article
- The neural correlates of shared and individual experience.Communications biology · 2026Article
- A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.Brain communications · 2026Article
- Decide, act, reflect, and maybe a self in all this?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Machine learning classification of functional neurological disorder using structural brain MRI features.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Dissociative Symptoms and Interoceptive Integration.Current topics in behavioral neurosciences · 2025Review
- Creativity and its link to epilepsy.Epilepsia open · 2024Review
- Cortical sites critical to language function act as connectors between language subnetworks.Nature communications · 2024Article
- Suspending the Embodied Self in Meditation Attenuates Beta Oscillations in the Posterior Medial Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The language network as a natural kind within the broader landscape of the human brain.Nature reviews. Neuroscience · 2024Review
- Depersonalization and derealization as sequelae of a temporal lobe lesion: a case report.BMC psychiatry · 2024Article
- Recent advances in the neuroscience of spontaneous and off-task thought: implications for mental health.Nature. Mental health · 2023Article
- Towards a pluralistic neurobiological understanding of consciousness.Trends in cognitive sciences · 2023Review
- Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology.Nature communications · 2023Article
- A tripartite view of the posterior cingulate cortex.Nature reviews. Neuroscience · 2023Review
- Neuroscience robotics for controlled induction and real-time assessment of hallucinations.Nature protocols · 2022Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The posteromedial cortex (PMC) is known to be a core node of the default mode network. Given its anatomical location and blood supply pattern, the effects of targeted disruption of this part of the brain are largely unknown. Here, we report a rare case of a patient (S19_137) with confirmed seizures originating within the PMC. Intracranial recordings confirmed the onset of seizures in the right dorsal posterior cingulate cortex, adjacent to the marginal sulcus, likely corresponding to Brodmann area 31. Upon the onset of seizures, the patient reported a reproducible sense of self-dissociation-a condition he described as a distorted awareness of the position of his body in space and feeling as if he had temporarily become an outside observer to his own thoughts, his "me" having become a separate entity that was listening to different parts of his brain speak to each other. Importantly, 50-Hz electrical stimulation of the seizure zone and a homotopical region within the contralateral PMC induced a subjectively similar state, reproducibly. We supplement our clinical findings with the definition of the patient's network anatomy at sites of interest using cortico-cortical-evoked potentials, experimental and resting-state electrophysiological connectivity, and individual-level functional imaging. This rare case of patient S19_137 highlights the potential causal importance of the PMC for integrating self-referential information and provides clues for future mechanistic studies of self-dissociation in neuropsychiatric populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.