Evidence map›Paper›PMID 34272258›Full record

ArticleeNeuro

Cellular and Behavioral Characterization of

Natalia Galindo-Riera, Sylvia Adriana Newbold, Monika Sledziowska, Cristina Llinares-Benadero, Jessica Griffiths, Erik Mire, Isabel Martinez-Garay

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. The intracellular domain of the epilepsy protein PCDH19 regulates spine density in cortical neurons in vivo viaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. iScience · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Natalia Galindo-RieraDivision of Neuroscience, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom.
Sylvia Adriana NewboldDivision of Neuroscience, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom.
Monika SledziowskaDivision of Neuroscience, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom.
Cristina Llinares-BenaderoDivision of Neuroscience, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom.
Jessica GriffithsDivision of Neuroscience, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom.
Erik MireHodge Centre for Neuropsychiatric Immunology, Neuroscience and Mental Health Research Institute, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Isabel Martinez-GarayDivision of Neuroscience, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom martinezgarayi@cardiff.ac.uk.
Cardiff University · GB

Funding

Wellcome TrustWellcome Trust 109643/Z/15/ZWellcome Trust 204021/Z/16/A
6 · The paper itself

Abstract

Mutations in the X-linked cell adhesion protein PCDH19 lead to seizures, cognitive impairment, and other behavioral comorbidities when present in a mosaic pattern. Neither the molecular mechanisms underpinning this disorder nor the function of PCDH19 itself are well understood. By combining RNA

Indexed as

CadherinsExploratory BehaviorAnimalsFemaleMiceMutationNeuronsSeizuresSocial EnvironmentCadherinscortical laminationimpact of mutant littermatesneuronal subtypesopen fieldsingle-cell RNAseq

Identifiers

PMID34272258
PMCPMC8362684
OpenAlexW3178881409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.