Evidence map›Paper›PMID 34272248›Full record

ArticleScience advances2021

Polycomb-group recruitment to a

Elnaz Ghotbi, Piao Ye, Taylor Ervin, Anni Kum, Judith Benes, Richard S Jones

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Nuclear architecture and the structural basis of mitotic memory.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023
    Review
  5. Variant Polycomb complexes inScience advances · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elnaz GhotbiDepartment of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA.ORCID http://orcid.org/0000-0002-6568-9553
Piao YeDepartment of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA.ORCID http://orcid.org/0000-0003-4268-313X
Taylor ErvinDepartment of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA.
Anni KumDepartment of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA.
Judith BenesDepartment of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA.
Richard S JonesDepartment of Biological Sciences, Southern Methodist University, Dallas, TX 75275-0376, USA. rjones@smu.edu.ORCID http://orcid.org/0000-0002-3751-2128
Southern Methodist University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
De novo establishment of Polycomb-group-mediated repressionR15GM094737 · NIGMS · SOUTHERN METHODIST UNIVERSITY · PI JONES, RICHARD S · 2010 to 2014
$781k
NIGMS NIH HHS R15 GM094737NIH HHS P40 OD018537
6 · The paper itself

Abstract

Polycomb-group (PcG) proteins are epigenetic regulators that maintain the transcriptional repression of target genes following their initial repression by transcription factors. PcG target genes are repressed in some cells, but active in others. Therefore, a mechanism must exist by which PcG proteins distinguish between the repressed and active states and only assemble repressive chromatin environments at target genes that are repressed. Here, we present experimental evidence that the repressed state of a

Identifiers

PMID34272248
PMCPMC8284896
OpenAlexW3181782449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.