ArticleScience advances2021
Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 85 citations in OpenAlex.
- Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson's disease.Communications biology · 2025Trial
- Trial
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- Cortex-wide Dynamics of Internal Decisions About Behavioral Context.bioRxiv : the preprint server for biology · 2026Article
- Visual-acoustic thigmotaxis in zebrafish larvae: a high throughput NAM for neurotoxicity assessment.Frontiers in toxicology · 2026Article
- Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study.PLoS computational biology · 2025Article
- Understanding the high-order network plasticity mechanisms of ultrasound neuromodulation.PLoS computational biology · 2025Article
- Catecholamines reduce choice history biases in perceptual decision making.PLoS biology · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Large-scale maps of altered cortical dynamics in early-stage psychosis are related to GABAergic and glutamatergic neurotransmission.Science advances · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The role of the prefrontal cortex in cocaine-induced noradrenaline release in the nucleus accumbens: a computational study.Biological cybernetics · 2025Article
- Toward a computational role for locus coeruleus/norepinephrine arousal systems.Current opinion in behavioral sciences · 2024Article
- Strategic stabilization of arousal boosts sustained attention.Current biology : CB · 2024Article
- The cognitive triad network - oscillation - behaviour links individual differences in EEG theta frequency with task performance and effective connectivity.Scientific reports · 2024Article
- Protocol and preregistration for the CODEC project: measuring, modelling and mechanistically understanding the nature of cognitive variability in early childhood.BMC psychology · 2024Article
- Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight.eNeuro · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influential theories postulate distinct roles of catecholamines and acetylcholine in cognition and behavior. However, previous physiological work reported similar effects of these neuromodulators on the response properties (specifically, the gain) of individual cortical neurons. Here, we show a double dissociation between the effects of catecholamines and acetylcholine at the level of large-scale interactions between cortical areas in humans. A pharmacological boost of catecholamine levels increased cortex-wide interactions during a visual task, but not rest. An acetylcholine boost decreased interactions during rest, but not task. Cortical circuit modeling explained this dissociation by differential changes in two circuit properties: the local excitation-inhibition balance (more strongly increased by catecholamines) and intracortical transmission (more strongly reduced by acetylcholine). The inferred catecholaminergic mechanism also predicted noisier decision-making, which we confirmed for both perceptual and value-based choice behavior. Our work highlights specific circuit mechanisms for shaping cortical network interactions and behavioral variability by key neuromodulatory systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.