Evidence map›Paper›PMID 34272233›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Differential Enhancement of Neutrophil Phagocytosis by Anti-Bactericidal/Permeability-Increasing Protein Antibodies.

Jomkuan Theprungsirikul, Sladjana Skopelja-Gardner, Rachel M Wierzbicki, Katherine J Sessions, William F C Rigby

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. iScience · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jomkuan TheprungsirikulDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH; and.ORCID 0000-0002-2139-9079
Sladjana Skopelja-GardnerDivision of Rheumatology, Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Rachel M WierzbickiDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH; and.
Katherine J SessionsDivision of Rheumatology, Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH.
William F C RigbyDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH; and william.f.c.rigby@dartmouth.edu.ORCID 0000-0002-1382-7299
Dartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Olympus FV1200 Near Infrared Confocal MicroscopeS10OD021616 · OD · DARTMOUTH COLLEGE · PI STAN, RADU VIRGIL · 2016 to 2016
$321k
NCI NIH HHS P30 CA023108NIH HHS S10 OD021616
6 · The paper itself

Abstract

Bactericidal/permeability-increasing protein (BPI) plays a major role in innate immunity through the ability of the N-terminal domain (NTD) to bind LPS, mediate cytotoxicity, and block LPS-induced inflammation. The C-terminal domain mediates phagocytosis of bacteria bound to the NTD. These two domains are linked by a surface-exposed loop at amino acids 231-249 for human BPI, known as the "hinge region." Autoantibodies to human BPI are prevalent in many chronic lung diseases; their presence is strongly correlated with

Indexed as

Cystic FibrosisNeutrophilsAnimalsAutoantibodiesBlood ProteinsHumansMembrane ProteinsMicePermeabilityPhagocytosisAutoantibodiesBlood ProteinsMembrane Proteins

Identifiers

PMID34272233
PMCPMC8354091
OpenAlexW3178020230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.