Evidence map›Paper›PMID 34272228›Full record

ArticleScience immunology2021

Extrathymic

Eva Gillis-Buck, Haleigh Miller, Marina Sirota, Stephan J Sanders, Vasilis Ntranos, Mark S Anderson, James M Gardner, Tippi C MacKenzie

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen-presenting cell network.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Facing stress and inflammation: From the cell to the planet.World journal of experimental medicine · 2024
    Review
  7. Thymic Mimetic Cells: Ontogeny as Immunology.Annual review of cell and developmental biology · 2024
    Review
  8. Aire in Autoimmunity.Annual review of immunology · 2024
    Review
  9. Review
  10. The emerging family of RORγtNature reviews. Immunology · 2024
    Review
  11. Article
  12. Extrathymic AIRE-Expressing Cells: A Historical Perspective.Advances in experimental medicine and biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eva Gillis-BuckDepartment of Surgery, University of California, San Francisco, CA, USA.ORCID 0000-0001-5071-9572
Haleigh MillerDepartment of Epidemiology and Biostatistics University of California, San Francisco, CA, USA.ORCID 0000-0002-0920-7169
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, CA, USA.ORCID 0000-0002-7246-6083
Stephan J SandersDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-9112-5148
Vasilis NtranosDepartment of Epidemiology and Biostatistics University of California, San Francisco, CA, USA.ORCID 0000-0002-2477-0670
Mark S AndersonDiabetes Center University of California, San Francisco, CA, USA.ORCID 0000-0002-3093-4758
James M GardnerDepartment of Surgery, University of California, San Francisco, CA, USA. tippi.mackenzie@ucsf.edu james.gardner@ucsf.edu.ORCID 0000-0003-3470-9520
Tippi C MacKenzieDepartment of Surgery, University of California, San Francisco, CA, USA. tippi.mackenzie@ucsf.edu james.gardner@ucsf.edu.ORCID 0000-0001-5232-809X
University of California, San Francisco · US

Funding

Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigensR01AI145858 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MACKENZIE, TIPPI · 2019 to 2023
$3.9M
Molecular Mechanisms of Rgg Receptor Regulation by Pheromones and InhibitorsR01AI125452 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI FEDERLE, MICHAEL J, NEIDITCH, MATTHEW B · 2016 to 2019
$1.9M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI125452NIAID NIH HHS R01 AI145858
6 · The paper itself

Abstract

Healthy pregnancy requires tolerance to fetal alloantigens as well as syngeneic embryonic and placental antigens. Given the importance of the autoimmune regulator (

Indexed as

Immune ToleranceAIRE ProteinAnimalsEpithelial CellsFemaleFetal Growth RetardationFetusMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicPlacentaPregnancyThymus GlandTranscription FactorsAIRE ProteinTranscription Factors

Identifiers

PMID34272228
PMCPMC9363019
OpenAlexW3178489433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.