Evidence map›Paper›PMID 34271979›Full record

ArticleTrials2021

Moderate-intensity exercise versus high-intensity interval training to recover walking post-stroke: protocol for a randomized controlled trial.

Allison Miller, Darcy S Reisman, Sandra A Billinger, Kari Dunning, Sarah Doren, Jaimie Ward, Henry Wright, Erin Wagner, Daniel Carl, Myron Gerson and 4 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03760016 nacompletednot on this map

Moderate-Intensity Exercise Versus High-Intensity Interval Training to Recover Walking Post-Stroke

TypeinterventionalSponsorUniversity of CincinnatiRan2019 to 2022Enrolled55ConditionsStrokeArmsModerate-Intensity Aerobic Training, High-Intensity Interval Training
NCT06292442 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of High-Intensity Interval Training on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled34ConditionsStrokeArmstraditional physical therapy, High intensity interval training
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  9. Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Allison MillerDepartment of Biomechanics and Movement Sciences Program, University of Delaware, Newark, DE, 19713, USA.
Darcy S ReismanDepartment of Biomechanics and Movement Sciences Program, University of Delaware, Newark, DE, 19713, USA.
Sandra A BillingerDepartment of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA.
Kari DunningDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, 3225 Eden Avenue, Cincinnati, OH, USA.
Sarah DorenDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, 3225 Eden Avenue, Cincinnati, OH, USA.
Jaimie WardDepartment of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA.
Henry WrightDepartment of Physical Therapy, University of Delaware, Newark, DE, 19713, USA.
Erin WagnerDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, 3225 Eden Avenue, Cincinnati, OH, USA.
Daniel CarlDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, 3225 Eden Avenue, Cincinnati, OH, USA.
Myron GersonDepartments of Cardiology and Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Oluwole AwosikaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.
Jane KhouryDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Brett KisselaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.
Pierce BoyneDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, 3225 Eden Avenue, Cincinnati, OH, USA. boynepe@ucmail.uc.edu.ORCID http://orcid.org/0000-0003-3611-9057
University of Cincinnati · USUniversity of Delaware · USUniversity of Kansas Medical Center · USCincinnati Children's Hospital Medical Center · USNutrition Sciences (Belgium) · BE

Funding

High-Intensity Interval Training to Recover Walking Post-Stroke: HIT-Stroke Trial 2R01HD093694 · NICHD · UNIVERSITY OF CINCINNATI · PI Pierce Boyne · 2018 to 2026
$6.1M
Foundation for Physical Therapy Research Florence P. Kendall Doctoral ScholarshipNICHD NIH HHS R01 HD093694NIH HHS R01HD093694
6 · The paper itself

Abstract

backgroundStroke results in neurologic impairments and aerobic deconditioning that contribute to limited walking capacity which is a major barrier post-stroke. Current exercise recommendations and stroke rehabilitation guidelines recommend moderate-intensity aerobic training post-stroke. Locomotor high-intensity interval training is a promising new strategy that has shown significantly greater improvements in aerobic fitness and motor performance than moderate-intensity aerobic training in other populations. However, the relative benefits and risks of high-intensity interval training and moderate-intensity aerobic training remain poorly understood following stroke. In this study, we hypothesize that locomotor high-intensity interval training will result in greater improvements in walking capacity than moderate-intensity aerobic training.

methodsUsing a single-blind, 3-site randomized controlled trial, 50 chronic (> 6 months) stroke survivors are randomly assigned to complete 36 locomotor training sessions of either high-intensity interval training or moderate-intensity aerobic training. Main eligibility criteria are age 40-80 years, single stroke for which the participant received treatment (experienced 6 months to 5 years prior to consent), walking speed ≤ 1.0 m/s, able to walk at least 3 min on the treadmill at ≥ 0.13 m/s (0.3 mph), stable cardiovascular condition (American Heart Association class B), and the ability to walk 10 m overground without continuous physical assistance. The primary outcome (walking capacity) and secondary outcomes (self-selected and fast gait speed, aerobic fitness, and fatigue) are assessed prior to initiating training and after 4 weeks, 8 weeks, and 12 weeks of training. DISCUSSION: This study will provide fundamental new knowledge to inform the selection of intensity and duration dosing parameters for gait recovery and optimization of aerobic training interventions in chronic stroke. Data needed to justify and design a subsequent definitive trial will also be obtained. Thus, the results of this study will inform future stroke rehabilitation guidelines on how to optimally improve walking capacity following stroke.

trial registrationClinicalTrials.gov NCT03760016 . Registered on November 30, 2018.

Indexed as

High-Intensity Interval TrainingStrokeStroke RehabilitationAdultAgedAged, 80 and overExercise TherapyHumansMiddle AgedRandomized Controlled Trials as TopicSingle-Blind MethodTreatment OutcomeWalkingAerobicClinical trialDoseGaitLocomotionOvergroundRehabilitationTreadmill

Identifiers

PMID34271979
PMCPMC8284012
OpenAlexW3176579818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.