Evidence map›Paper›PMID 34271911›Full record

ArticleWorld journal of surgical oncology2021

Risk factors for radiation-induced lung injury in patients with advanced non-small cell lung cancer: implication for treatment strategies.

Sha Sha, Jigang Dong, Maoyu Wang, Ziyu Chen, Peng Gao

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06079931 (The Efficacy of Babaodan Capsules in Preventing Radiation Pneumonitis in Locally Advanced Non-Small Cell Lung Cancer Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06079931 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

The Efficacy of Babaodan Capsules in Preventing Radiation Pneumonitis in Locally Advanced Non-Small Cell Lung Cancer Patients: A Phase II Clinical Trial

TypeinterventionalSponsorFifth Affiliated Hospital, Sun Yat-Sen UniversityRan2024 to 2025Enrolled30ConditionsRadiation PneumonitisArmsBabaodan Capsule
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.Clinical and translational radiation oncology · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sha ShaDepartment of Radiotherapy, Jiaozhou Central Hospital, No. 29 Xuzhou Road, Jiaozhou City, Qingdao, 266300, China. shasha_qjch@yeah.net.
Jigang DongDepartment of Radiotherapy, Jiaozhou Central Hospital, No. 29 Xuzhou Road, Jiaozhou City, Qingdao, 266300, China.
Maoyu WangDepartment of Radiotherapy, Jiaozhou Central Hospital, No. 29 Xuzhou Road, Jiaozhou City, Qingdao, 266300, China.
Ziyu ChenDepartment of Radiotherapy, Jiaozhou Central Hospital, No. 29 Xuzhou Road, Jiaozhou City, Qingdao, 266300, China.
Peng GaoDepartment of Radiotherapy, Jiaozhou Central Hospital, No. 29 Xuzhou Road, Jiaozhou City, Qingdao, 266300, China.
Shuozhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe radiation-induced lung injury (RILI) in patients with advanced non-small cell lung cancer (NSCLS) is very common in clinical settings; we aimed to evaluate the risk factors of RILI in NSCLS patients, to provide insights into the treatment of NSCLS.

methodsNSCLC patients undergoing three-dimensional conformal radiotherapy (3D-CRT) in our hospital from June 1, 2018, to June 30, 2020, were included. The characteristics and treatments of RILI and non-RILI patients were analyzed. Logistic regression analyses were conducted to assess the risk factors of RILI in patients with NSCLC.

resultsA total of 126 NSCLC patients were included; the incidence of RILI in NSCLC patients was 35.71%. There were significant differences in diabetes, smoke, chronic obstructive pulmonary disease (COPD), concurrent chemotherapy, radiotherapy dose, and planning target volume (PTV) between the RILI group and the non-RILI group (all P < 0.05). Logistic regression analyses indicated that diabetes (OR 3.076, 95%CI 1.442~5.304), smoke (OR 2.745, 95%CI 1.288~4.613), COPD (OR 3.949, 95%CI 1.067~5.733), concurrent chemotherapy (OR 2.072, 95%CI 1.121~3.498), radiotherapy dose ≥ 60 Gy (OR 3.841, 95%CI 1.932~5.362), and PTV ≥ 396 (OR 1.247, 95%CI 1.107~1.746) were the independent risk factors of RILI in patients with NSCLC (all P < 0.05).

conclusionsRILI is commonly seen in NSCLS patients; early targeted measures are warranted for patients with those risk factors; future studies with larger sample sizes and different areas are needed to further elucidate the influencing factors of RILI in the treatment of NSCLS.

Indexed as

Carcinoma, Non-Small-Cell LungLung InjuryLung NeoplasmsRadiotherapy, ConformalHumansPrognosisRadiotherapy DosageRisk FactorsCareLung injuryNon-small cell lung cancerRadiationTreatment

Identifiers

PMID34271911
PMCPMC8285849
OpenAlexW3178058426

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.