Evidence map›Paper›PMID 34271207›Full record

Observational studyJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2021

A prospective study of treatments for adult-onset divergence insufficiency-type esotropia.

Eric R Crouch, Trevano W Dean, Raymond T Kraker, Aaron M Miller, Courtney L Kraus, Kammi B Gunton, Michael X Repka, Justin D Marsh, Monte A Del Monte, Paula A Luke and 8 more

Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph

Observational study in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02510040 (A Prospective Observational Study of Adult Strabismus), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02510040 completednot on this map

A Prospective Observational Study of Adult Strabismus

TypeobservationalSponsorJaeb Center for Health ResearchRan2015 to 2019Enrolled217ConditionsConvergence Insufficiency, Divergence Insufficiency, HypertropiaArmsPrism, Orthoptic Exercises, Eye Muscle Surgery, Botox Injection
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Doses of medial rectus muscle recessions for divergence insufficiency-type esotropia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2024
    Article
  7. Article
  8. Evaluation and Management of Divergence Insufficiency-Type Esotropia.Journal of binocular vision and ocular motility
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 1 country.

Eric R CrouchVirginia Pediatric Eye Center, Virginia Beach, Virginia. Electronic address: ercrouch@gmail.com.
Trevano W DeanJaeb Center for Health Research, Tampa, Florida.
Raymond T KrakerJaeb Center for Health Research, Tampa, Florida.
Aaron M MillerHouston Eye Associates, The Woodlands, Texas.
Courtney L KrausWilmer Eye Institute, Baltimore, Maryland.
Kammi B GuntonWills Eye Hospital, Philadelphia, Pennsylvania.
Michael X RepkaWilmer Eye Institute, Baltimore, Maryland.
Justin D MarshChildren's Mercy Hospitals and Clinics, Kansas City, Missouri.
Monte A Del MonteWK Kellogg Eye Center, University of Michigan, Ann Arbor.
Paula A LukePacific University College of Optometry, Portland, Oregon.
Jason H PeragalloEmory Eye Center, Atlanta, Georgia.
Katherine A LeeSt. Luke's Hospital, Boise, Idaho.
Maynard B WheelerConcord Ophthalmologic Associates, Concord, New Hampshire.
Timothy J DaleyMedical Associates Clinic, Dubuque, Iowa.
David K WallaceIndiana University School of Medicine, Indianapolis, Indiana.
Susan A CotterSouthern California College of Optometry at Marshall B. Ketchum University, Fullerton, California.
Jonathan M HolmesUniversity of Arizona, Tucson, Arizona.
Pediatric Eye Disease Investigator Group
Jaeb Center for Health Research · USNational Eye Institute · USChildren's Mercy Hospital · USConcord Consortium · USEmory Eye Center · USHouston Eye Associates · USIndiana University School of MedicineMarshall B. Ketchum University · USPacific University Oregon · USSt. Luke's Hospital · USUniversity of Arizona · USVirginia Eye Consultants · USWills Eye Hospital · USW.K. Kellogg Foundation · US

Funding

Pediatric Eye Disease Investigator Group Coordinating CenterU10EY011751 · NEI · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI KRAKER, RAYMOND · 1997 to 2018
$75.2M
Pediatric Eye Disease Investigator Group NetworkUG1EY011751 · NEI · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI Raymond Kraker, Stacy Pineles · 2019 to 2026
$53.7M
Pediatric Eye Disease Investigator Group: Chair's OfficeU10EY018810 · NEI · MAYO CLINIC ROCHESTER · PI HOLMES, JONATHAN M · 2009 to 2013
$3.5M
Outcome Measures for Clinical Trials in Pediatric Eye Care and StrabismusR01EY024333 · NEI · MAYO CLINIC ROCHESTER · PI FAUTSCH, MICHAEL P. · 2014 to 2018
$3.3M
PEDIATRIC EYE DISEASE INVESTIGATOR GROUP: CHAIR'S OFFICEU10EY023198 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI WALLACE, DAVID K · 2014 to 2018
$1.4M
NEI NIH HHS R01 EY024333NEI NIH HHS U10 EY011751NEI NIH HHS U10 EY018810NEI NIH HHS U10 EY023198NEI NIH HHS UG1 EY011751
6 · The paper itself

Abstract

purposeTo describe 10-week and 12-month outcomes following treatment for divergence insufficiency-type esotropia in adults.

methodsIn this prospective observational study, 110 adults with divergence insufficiency-type esotropia, with a distance esodeviation measuring 2

resultsOf the 110 participants, 32 (29%) were prescribed base-out prism; none had received prior treatment for esotropia. Success criteria were met by 22 of 30 at 10 weeks (73%; 95% CI, 54%-88%) and by 16 of 26 at 12 months (62%; 95% CI, 41%-80%). For the 76 (68%) who underwent strabismus surgery (82% of whom had been previously treated with prism), success criteria were met by 69 of 74 at 10 weeks (93%; 95% CI, 85%-98%) and by 57 of 72 at 12 months (79%; 95% CI, 68%-88%).

conclusionsIn this study cohort, both base-out prism as initial therapy and strabismus surgery (usually following prism) were successful in treating diplopia for most adults with divergence insufficiency-type esotropia when assessed during the first year of follow-up.

Indexed as

EsotropiaStrabismusAdultHumansOculomotor MusclesOphthalmologic Surgical ProceduresProspective StudiesRetrospective StudiesTreatment OutcomeVision, Binocular

Identifiers

PMID34271207
PMCPMC9703348
OpenAlexW3181410942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.