Evidence map›Paper›PMID 34271017›Full record

ArticleNeuropharmacology2021

Ionic and signaling mechanisms involved in neurotensin-mediated excitation of central amygdala neurons.

Saobo Lei, Binqi Hu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Saobo LeiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND58203, USA. Electronic address: saobo.lei@und.edu.
Binqi HuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND58203, USA.
University of North Dakota · US

Funding

Cellular and molecular mechanisms of vasopressin in anxietyR01MH118258 · NIMH · UNIVERSITY OF NORTH DAKOTA · PI LEI, SAOBO · 2019 to 2023
$1.5M
NIMH NIH HHS R01 MH118258
6 · The paper itself

Abstract

Neurotensin (NT) serves as a neuromodulator in the brain where it regulates a variety of physiological functions. Whereas the central amygdala (CeA) expresses NT peptide and NTS1 receptors and application of NT has been shown to excite CeA neurons, the underlying cellular and molecular mechanisms have not been determined. We found that activation of NTS1 receptors increased the neuronal excitability of the lateral nucleus (CeL) of CeA. Both phospholipase Cβ (PLCβ) and phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Action PotentialsAnimalsCentral Amygdaloid NucleusGTP-Binding ProteinsInhibitory Postsynaptic PotentialsMembrane PotentialsMiniature Postsynaptic PotentialsNeuronsNeurotensinPatch-Clamp TechniquesPhospholipase C betaRatsReceptors, NeurotensinSignal TransductionGTP-Binding ProteinsNeurotensinneurotensin type 1 receptorPhospholipase C betaReceptors, NeurotensinAction potentialExcitabilityGABAG proteinK(+) channelsPeptidePIP(2)ReceptorSynapse

Identifiers

PMID34271017
PMCPMC8435002
OpenAlexW3182804723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.