ArticleChest2021
Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging.
Article in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A Comprehensive Review of Artificial Intelligence (AI) Applications in Pulmonary Hypertension (PH).Medicina (Kaunas, Lithuania) · 2025Pooled it
- Reply to the Letter to the Editor: Methodological considerations regarding the association between emphysema and pulmonary vascular volume heterogeneity.European radiology · 2026Article
- Pulmonary vascular volume heterogeneity in association with emphysema: a multicenter study based on non-contrast chest CT.European radiology · 2026Article
- The clinical relevance of chest computed tomography imaging in pulmonary hypertension associated with lung diseases.Current opinion in pulmonary medicine · 2026Review
- AI-based CT quantification reveals small airway loss and vascular simplification in rheumatoid arthritis-associated lung disease.Clinical rheumatology · 2026Article
- Artificial Intelligence and Multi-Omics Approaches in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification.International journal of molecular sciences · 2026Review
- A large animal model of heritable pulmonary arterial hypertension using BMPR2 gene-edited sheep.JCI insight · 2026Article
- Article
- Quantification of chronic vascular remodeling in sickle cell disease.European radiology · 2026Article
- Artificial Intelligence in Pulmonary Hypertension: Current State and Future Prospects.Reviews in cardiovascular medicine · 2026Review
- Identification of pulmonary hypertension with pulmonary vascular surface volume ratio by non-contrast CT.BMC cardiovascular disorders · 2026Article
- Automated CT Pulmonary Angiography-Derived Periclot Radiomics for CTEPH Detection.Pulmonary circulation · 2026Article
- Increased Venous Volumes in Response to Catheter-Based Intervention for Acute PE: Lessons From the OPTALYSE PE Trial (OPTALYSE-3D).Circulation. Cardiovascular imaging · 2026Article
- Pulmonary vascular features on chest computed tomography differentially associate with adverse outcomes in smokers in COPDGene.Annals of the American Thoracic Society · 2026Article
- Pulmonary Artery and Vein Morphology as an Imaging Biomarker for the Diagnosis of Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2026Article
- A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-editedbioRxiv : the preprint server for biology · 2026Article
- An applied study on the assessment of concomitant pulmonary hypertension in patients with chronic obstructive pulmonary disease based on whole-lung CT imaging histologic features.Journal of thoracic disease · 2026Article
- Anthropometry, sex, and age at diagnosis affect pulmonary blood volume quantification from computed tomography pulmonary angiography in pulmonary hypertension assessment.Frontiers in cardiovascular medicine · 2026Article
- AI-based prediction of pulmonary hypertension in COPD patients with cor pulmonale using clinical and CT features.Frontiers in medicine · 2026Article
- Spatial heterogeneity and distribution of CT-Based pulmonary vascular volumes in chronic thromboembolic pulmonary hypertension.European journal of radiology · 2025Article
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14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPulmonary hypertension is a heterogeneous disease, and a significant portion of patients at risk for it have CT imaging available. Advanced automated processing techniques could be leveraged for early detection, screening, and development of quantitative phenotypes. Pruning and vascular tortuosity have been previously described in pulmonary arterial hypertension (PAH), but the extent of these phenomena in arterial vs venous pulmonary vasculature and in exercise pulmonary hypertension (ePH) have not been described. RESEARCH QUESTION: What are the arterial and venous manifestations of pruning and vascular tortuosity using CT imaging in PAH, and do they also occur in ePH? STUDY DESIGN AND
methodsA cohort of patients with PAH and ePH and control subjects with available CT angiograms were retrospectively identified to examine the differential arterial and venous presence of pruning and tortuosity in patients with precapillary pulmonary hypertension not confounded by lung or thromboembolic disease. The pulmonary vasculature was reconstructed, and an artificial intelligence method was used to separate arteries and veins and to compute arterial and venous vascular volumes and tortuosity.
resultsA total of 42 patients with PAH, 12 patients with ePH, and 37 control subjects were identified. There was relatively lower (median [interquartile range]) arterial small vessel volume in subjects with PAH (PAH 14.7 [11.7-16.5; P < .0001]) vs control subjects (16.9 [15.6-19.2]) and venous small vessel volume in subjects with PAH and ePH (PAH 8.0 [6.5-9.6; P < .0001]; ePH, 7.8 [7.5-11.4; P = .004]) vs control subjects (11.5 [10.6-12.2]). Higher large arterial volume, however, was only observed in the pulmonary arteries (PAH 17.1 [13.6-23.4; P < .0001] vs control subjects 11.4 [8.1-15.4]). Similarly, tortuosity was higher in the pulmonary arteries in the PAH group (PAH 3.5 [3.3-3.6; P = .0002] vs control 3.2 [3.2-3.3]).
interpretationLower small distal pulmonary vascular volume, higher proximal arterial volume, and higher arterial tortuosity were observed in PAH. These can be quantified by using automated techniques from clinically acquired CT scans of patients with ePH and resting PAH.
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