Evidence map›Paper›PMID 34270950›Full record

ArticleCurrent biology : CB2021

Sensory cilia act as a specialized venue for regulated extracellular vesicle biogenesis and signaling.

Juan Wang, Inna A Nikonorova, Malan Silva, Jonathon D Walsh, Peter E Tilton, Amanda Gu, Jyothi S Akella, Maureen M Barr

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The extracellular matrix genebioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Superoxide dismutase impacts extracellular vesicle biogenesis and uptake.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Review
  11. bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Juan WangDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: juwang07@hginj.rutgers.edu.
Inna A NikonorovaDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
Malan SilvaSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Jonathon D WalshDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
Peter E TiltonDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
Amanda GuDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
Jyothi S AkellaDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
Maureen M BarrDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: mmbarr@hginj.rutgers.edu.
Rutgers, The State University of New Jersey · USUniversity of Utah · US

Funding

IRACDA at Rutgers: INSPIRE Postdoctoral Training ProgramK12GM093854 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Detlev Boison, Gary A. Brewer · 2010 to 2026
$14.7M
Polycystins, cilia, and extracellular vesicles in C. elegansR01DK059418 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Maureen M Barr · 2001 to 2026
$9.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Pilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5M
Nephronophthisis-related ciliopathies and ciliary specializationR01DK116606 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI Maureen M Barr · 2018 to 2026
$3.7M
Fundamental biology of neuronal extracellular vesicles - RenewalRF1NS120745 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI Maureen M Barr · 2021 to 2026
$3.0M
NIDDK NIH HHS P30 DK106912NIDDK NIH HHS R01 DK059418NIDDK NIH HHS R01 DK116606NIGMS NIH HHS K12 GM093854NIH HHS P40 OD010440NINDS NIH HHS RF1 NS120745
6 · The paper itself

Abstract

Ciliary extracellular vesicle (EV) shedding is evolutionarily conserved. In Chlamydomonas and C. elegans, ciliary EVs act as signaling devices.

Indexed as

Caenorhabditis elegans ProteinsExtracellular VesiclesAnimalsCaenorhabditis elegansCiliaMaleMammalsProtein TransportCaenorhabditis elegans ProteinsC. elegansciliaectosomesexosomesextracellular vesicleskinesin-2kinesin-3myristoylationpolycystinsuper-resolution microscopy

Identifiers

PMID34270950
PMCPMC8440419
OpenAlexW3180370962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.