Evidence map›Paper›PMID 34270374›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Voltage-gated potassium channel dysfunction in dorsal root ganglia contributes to the exaggerated exercise pressor reflex in rats with chronic heart failure.

Juan Hong, Shubin Fu, Lie Gao, Yanhui Cai, Eric Lazartigues, Han-Jun Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Juan HongDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska.
Shubin FuDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska.
Lie GaoDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Yanhui CaiDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Eric LazartiguesDepartment of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana.ORCID 0000-0001-7290-0786
Han-Jun WangDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0001-5906-8980
University of Nebraska Medical Center · USLouisiana State University Health Sciences Center New Orleans · USSouthwest University · CN

Funding

Cardiac Sympathetic Afferent Denervation and Remodeling in Heart FailureR01HL126796 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, HANJUN, ZUCKER, IRVING H · 2016 to 2023
$4.3M
Targeting ADAM17 maturation in resistant hypertension.R01HL163588 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LAZARTIGUES, ERIC D · 2022 to 2025
$2.2M
Novel Neural Mechanisms underlying Lung-Heart Pathological CrosstalkR01HL152160 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, HANJUN · 2020 to 2023
$2.2M
BDNF and the Exercise Pressor Reflex in Heart Fail.ureR01HL121012 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, HANJUN · 2016 to 2019
$1.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01 HL-121012HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01 HL-152160HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL126796NHLBI NIH HHS R01 HL121012NHLBI NIH HHS R01 HL126796NHLBI NIH HHS R01 HL152160NHLBI NIH HHS R01 HL163588
6 · The paper itself

Abstract

An exaggerated exercise pressor reflex (EPR) causes excessive sympathoexcitation and exercise intolerance during physical activity in the chronic heart failure (CHF) state. Muscle afferent sensitization contributes to the genesis of the exaggerated EPR in CHF. However, the cellular mechanisms underlying muscle afferent sensitization in CHF remain unclear. Considering that voltage-gated potassium (Kv) channels critically regulate afferent neuronal excitability, we examined the potential role of Kv channels in mediating the sensitized EPR in male rats with CHF. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting experiments demonstrate that both mRNA and protein expressions of multiple Kv channel isoforms (Kv1.4, Kv3.4, Kv4.2, and Kv4.3) were downregulated in lumbar dorsal root ganglions (DRGs) of CHF rats compared with sham rats. Immunofluorescence data demonstrate significant decreased Kv channel staining in both NF200-positive and IB4-positive lumbar DRG neurons in CHF rats compared with sham rats. Data from patch-clamp experiments demonstrate that the total Kv current, especially

Indexed as

Reflex, AbnormalAfferent PathwaysAnimalsDisease Models, AnimalExercise ToleranceGanglia, SpinalHeart FailureKv1.4 Potassium ChannelMaleMuscle, SkeletalNeurons, AfferentPatch-Clamp TechniquesPotassium Channels, Voltage-GatedRatsRats, Sprague-DawleyReflexKcna4 protein, ratKcnc4 protein, ratKcnd2 protein, ratKcnd3 protein, ratKv1.4 Potassium ChannelPotassium Channels, Voltage-GatedShal Potassium ChannelsShaw Potassium Channelsexerciseion channelsmechanoreflexmyocardial infarctionsympathoexcitation

Identifiers

PMID34270374
PMCPMC8410124
OpenAlexW3179764542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.