Evidence map›Paper›PMID 34270123›Full record

ArticleMagnetic resonance in medicine2021

MASiVar: Multisite, multiscanner, and multisubject acquisitions for studying variability in diffusion weighted MRI.

Leon Y Cai, Qi Yang, Praitayini Kanakaraj, Vishwesh Nath, Allen T Newton, Heidi A Edmonson, Jeffrey Luci, Benjamin N Conrad, Gavin R Price, Colin B Hansen and 9 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Scalable, reproducible, and cost-effective processing of large-scale medical imaging datasets.Proceedings of SPIE--the International Society for Optical Engineering · 2025
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  18. Diffusion MRI with Machine Learning.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Leon Y CaiDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-5812-5397
Qi YangDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Praitayini KanakarajDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Vishwesh NathDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Allen T NewtonDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Heidi A EdmonsonDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Jeffrey LuciDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Benjamin N ConradNeuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-3755-6988
Gavin R PriceDepartment of Psychology and Human Development, Peabody College, Vanderbilt University, Nashville, Tennessee, USA.
Colin B HansenDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Cailey I KerleyDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Karthik RamadassDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Fang-Cheng YehDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Hakmook KangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Eleftherios GaryfallidisDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, USA.
Maxime DescoteauxDepartment of Computer Science, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Francois RheaultDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Kurt G SchillingDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Bennett A LandmanDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-5733-2127

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
National Institutes of Health (NIH) 1UL1RR024975National Institutes of Health (NIH) 5R01EB017230National Institutes of Health (NIH) 5T32EB001628National Institutes of Health (NIH) 5T32GM007347NCRR NIH HHS UL1 RR024975NIBIB NIH HHS R01 EB017230NIBIB NIH HHS T32 EB001628NICHD NIH HHS P50 HD103537NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

purposeDiffusion-weighted imaging allows investigators to identify structural, microstructural, and connectivity-based differences between subjects, but variability due to session and scanner biases is a challenge.

methodsTo investigate DWI variability, we present MASiVar, a multisite data set consisting of 319 diffusion scans acquired at 3 T from b = 1000 to 3000 s/mm

resultsWe plot the variability in these measures at each level and find that it consistently increases with intrasession to intersession to interscanner to intersubject effects across all processing approaches and that sometimes interscanner variability can approach intersubject variability.

conclusionsThis study demonstrates the potential of MASiVar to more globally investigate DWI variability across multiple levels and processing approaches simultaneously and suggests harmonization between scanners for multisite analyses should be considered before inference of group differences on subjects.

Indexed as

Diffusion Tensor ImagingWhite MatterAdultAnisotropyBrainChildDiffusion Magnetic Resonance ImagingHumansNeuritesbundle segmentationconnectomeDTINODDIreproducibilityvariability

Identifiers

PMID34270123
PMCPMC9087815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.