Evidence map›Paper›PMID 34270107›Full record

ArticleMicrobiology and immunology2021

Validation of serum apolipoprotein A1 in rabies virus-infected mice as a biomarker for the preclinical diagnosis of rabies.

Kentaro Yamada, Koji Kuribayashi, Naotaka Inomata, Kazuko Noguchi, Kazunori Kimitsuki, Catalino S Demetria, Nobuo Saito, Satoshi Inoue, Chun-Ho Park, Ryo Kaimori and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Microbiology and immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Kentaro YamadaDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.ORCID http://orcid.org/0000-0001-5454-4554
Koji KuribayashiDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.
Naotaka InomataDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.
Kazuko NoguchiDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.
Kazunori KimitsukiDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.ORCID https://orcid.org/0000-0002-7203-0466
Catalino S DemetriaDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.ORCID https://orcid.org/0000-0002-9212-1429
Nobuo SaitoDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.ORCID https://orcid.org/0000-0002-4396-5000
Satoshi InoueDepartment of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan.
Chun-Ho ParkDepartment of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Ryo KaimoriDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.
Motoi SuzukiInfectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8340-0880
Mariko Saito-ObataDepartment of Virology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Yasuhiko KamiyaSchool of Tropical Medicine & Global Health, Nagasaki University, Nagasaki, Japan.ORCID https://orcid.org/0000-0001-7190-1082
Daria L ManaloVeterinary Research Department, Research Institute for Tropical Medicine, Muntinlupa City, Philippines.
Beatriz P QuiambaoResearch Institute for Tropical Medicine, Muntinlupa City, Philippines.ORCID https://orcid.org/0000-0003-2916-3199
Akira NishizonoDepartment of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.ORCID https://orcid.org/0000-0002-1364-4839
Oita University · JPNational Institute of Infectious Diseases · JPResearch Institute for Tropical Medicine · PHKitasato University · JPNagasaki University · JPTohoku University · JPUniversity of Miyazaki · JP

Funding

Japan Agency for Medical Research and Development (AMED)/JICAScience and Technology Research Partnership for Sustainable Development (SATREPS) 17823721
6 · The paper itself

Abstract

Rabies is a type of acute fetal encephalitis caused by rabies virus (RABV). While it becomes incurable after symptom onset, it can be prevented by post-exposure prophylaxis (PEP) during the long incubation period. While preclinical diagnosis aids the appropriate PEP administration, it is mostly nonfeasible owing to the absence of viremia or a specific antibody response during the incubation period. Here, an attempt was made to identify a serum biomarker for the preclinical diagnosis of rabies. Using the serum from a mouse inoculated intramuscularly (i.m.) with 5 × 10

Indexed as

RabiesRabies virusAnimalsAntibodies, ViralApolipoprotein A-IBiomarkersMiceAntibodies, ViralApolipoprotein A-IBiomarkersApoA1biomarkerin vivo imagingproteomicsrabies

Identifiers

PMID34270107
PMCPMC9292310
OpenAlexW3182733164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.