Evidence map›Paper›PMID 34270097›Full record

ArticleJournal of surgical oncology2021

Radiological assessment of persistent retroperitoneal and lateral pelvic lymph nodes after neoadjuvant therapy for rectal cancer: An analysis of the United States Rectal Cancer Consortium.

Michael K Turgeon, Adriana C Gamboa, Jessica M Keilson, Jeffrey Maniko, Lillias Maguire, Katherine Hrebinko, Jennifer Holder-Murray, Jason T Wiseman, Sherif Abdel-Misih, Saif Hamdan and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Michael K TurgeonDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0001-7197-9007
Adriana C GamboaDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0002-5464-2178
Jessica M KeilsonDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Jeffrey ManikoDepartment of Surgery, Division of Colorectal Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Lillias MaguireDepartment of Surgery, Division of Colorectal Surgery, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-6041-2416
Katherine HrebinkoDepartment of Surgery, Division of Colon and Rectal Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Jennifer Holder-MurrayDepartment of Surgery, Division of Colon and Rectal Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Jason T WisemanDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
Sherif Abdel-MisihDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
Saif HamdanSection of Colon & Rectal Surgery, Division of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexander T HawkinsSection of Colon & Rectal Surgery, Division of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Philip BauerDepartment of Surgery, Section of Colon & Rectal Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Matthew SilvieraDepartment of Surgery, Section of Colon & Rectal Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Shishir K MaithelDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Glen C BalchDepartment of Surgery, Division of Colon & Rectal Surgery, Emory University, Atlanta, Georgia, USA.
Emory University · USOhio State University Hospital · USUniversity of Michigan · USUniversity of Pittsburgh Medical Center · USVanderbilt University Medical Center · USWashington University in St. Louis · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
Abraham J. and Phyllis Katz FoundationNCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NCATS NIH HHS UL1TR002378/TL1TR002382
6 · The paper itself

Abstract

introductionManagement of retroperitoneal and lateral pelvic lymph nodes (RLPN) in rectal cancer remains unclear. With total neoadjuvant therapy (TNT), more patients have radiologic complete clinical response (rCR). We sought to evaluate the impact of radiographic persistent RLPN after neoadjuvant therapy on survival. MATERIALS AND

methodsPatients with rectal adenocarcinoma with isolated RLPN metastasis, who received neoadjuvant therapy before surgery were included from the United States Rectal Cancer Consortium database. Primary outcomes were recurrence-free survival (RFS) and overall survival (OS).

resultsOf 77 patients, all received neoadjuvant therapy, with 35 (46%) receiving TNT. Posttreatment, 33 (43%) had rCR while 44 (57%) had radiographic persistent RLPN. Median number of radiographic positive RLPN was 1 (IQR 1-2). Receipt of TNT was associated with radiographic RLPN rCR (OR 4.77, 95% CI 1.81-12.60, p < .01). However, there was no difference in RFS and OS between patients who achieved rCR or with persistent RLPN (all p > .05).

conclusionsRadiographic persistence of RLPN was not associated with worse survival in well-selected patients and may not be a reliable indicator of pathological response. TNT may be the preferred management strategy to select patients given its association with rCR. Radiographic persistence of RLPN after preoperative therapy should not necessarily preclude surgery.

Indexed as

AdenocarcinomaFemaleFollow-Up StudiesHumansLymph NodesMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPelvisPrognosisRectal NeoplasmsRetroperitoneal SpaceRetrospective StudiesSurvival RateTomography, X-Ray Computedneoadjuvant therapyrectal cancerretroperitoneal lateral pelvic lymph nodestotal neoadjuvant therapy

Identifiers

PMID34270097
PMCPMC8433488
OpenAlexW3182245990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.