Evidence map›Paper›PMID 34269964›Full record

ArticleMolecular neurobiology2021

Latent Tri-lineage Potential of Human Menstrual Blood-Derived Mesenchymal Stromal Cells Revealed by Specific In Vitro Culture Conditions.

Diana Quintero-Espinosa, Viviana Soto-Mercado, Catherine Quintero-Quinchia, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Polycationic peptide RBiochemistry and biophysics reports · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Diana Quintero-Espinosa *Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University Research Center (URC), University of Antioquia (UdeA), Calle 70 no. 52-21, and Calle 62 no. 52-59, Building 1, Room 412, Medellin, Colombia.
Viviana Soto-Mercado *Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University Research Center (URC), University of Antioquia (UdeA), Calle 70 no. 52-21, and Calle 62 no. 52-59, Building 1, Room 412, Medellin, Colombia.
Catherine Quintero-Quinchia *Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University Research Center (URC), University of Antioquia (UdeA), Calle 70 no. 52-21, and Calle 62 no. 52-59, Building 1, Room 412, Medellin, Colombia.
Miguel Mendivil-PerezNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, University Research Center (URC), University of Antioquia (UdeA), Calle 70 no. 52-21, and Calle 62 no. 52-59, Building 1, Room 412, Medellin, Colombia.
Carlos Velez-Pardo *Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University Research Center (URC), University of Antioquia (UdeA), Calle 70 no. 52-21, and Calle 62 no. 52-59, Building 1, Room 412, Medellin, Colombia.ORCID http://orcid.org/0000-0002-0557-0411
Marlene Jimenez-Del-RioNeuroscience Research Group, Medical Research Institute, Faculty of Medicine, University Research Center (URC), University of Antioquia (UdeA), Calle 70 no. 52-21, and Calle 62 no. 52-59, Building 1, Room 412, Medellin, Colombia. marlene.jimenez@udea.edu.co.ORCID http://orcid.org/0000-0003-3477-2386
Universidad de Antioquia · CO

Funding

MinCiencias 1115-807-62912
6 · The paper itself

Abstract

Human menstrual blood-derived mesenchymal stromal cells (MenSCs) have become not only an important source of stromal cells for cell therapy but also a cellular source for neurologic disorders in vitro modeling. By using culture protocols originally developed in our laboratory, we show that MenSCs can be converted into floating neurospheres (NSs) using the Fast-N-Spheres medium for 24-72 h and can be transdifferentiated into functional dopaminergic-like (DALNs, ~ 26% TH + /DAT + flow cytometry) and cholinergic-like neurons (ChLNs, ~ 46% ChAT + /VAChT flow cytometry) which responded to dopamine- and acetylcholine-triggered neuronal Ca

Indexed as

AdolescentAdultCell LineageCells, CulturedCell TransdifferentiationCholinergic NeuronsDopaminergic NeuronsFemaleHumansMenstruationMesenchymal Stem CellsYoung AdultAstrocyteCalciumCholinergicDopaminergicMenstrual bloodNeurogenicStromal

Identifiers

PMID34269964
OpenAlexW3181775992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.