ArticleEuropean journal of clinical pharmacology2021
Successful deprescribing of proton pump inhibitors with a patient-centered process: the DESPIBP Project.
Article in European journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Efficacy of a computer based discontinuation strategy to reduce PPI prescriptions: a multicenter cluster-randomized controlled trial.Scientific reports · 2023Trial
- Deprescribing of proton pump inhibitors in internal medicine in-patients: A retrospective observational study.Exploratory research in clinical and social pharmacy · 2026Article
- Internists' deprescribing behavior for proton pump inhibitor therapy: a qualitative study based on the theoretical domains framework internists' deprescribing behavior for PPI therapy.BMC health services research · 2026Article
- [Health outcomes of deprescribing proton pump inhibitors: study protocol].Revista espanola de salud publica · 2025Article
- Article
- Approaches to Deprescribing Proton Pump Inhibitors in Clinical Practice: A Systematic Review.Journal of clinical medicine · 2024Review
- Maintenance proton pump inhibitor use and risk of colorectal cancer: a Swedish retrospective cohort study.BMJ open · 2024Article
- Determinants of and interventions for Proton Pump Inhibitor prescription behavior: A systematic scoping review.BMC primary care · 2024Article
- Inappropriate proton pump inhibitor lansoprazole prescription in older adults hospitalized in long-term care unit.Irish journal of medical science · 2023Article
- Evaluating physicians' awareness and prescribing trends regarding proton pump inhibitors: a cross-sectional study.Frontiers in pharmacology · 2023Article
- Impact of Specialized Clinics on Medications Deprescribing in Older Adults: A Pilot Study in Ambulatory Care Clinics in a Teaching Hospital.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProton-pump inhibitors (PPIs) are among the most frequently prescribed drugs, but they are being overprescribed.
objectiveTo evaluate the applicability of a deprescription algorithm in hospitalized patients with chronic PPI use.
methodsA prospective study including consecutive gastroenterology department hospitalized patients with chronic PPI use. The prescription was reassessed and a deprescribing algorithm was applied. Follow-up was carried out at 4, 12, and 24 weeks.
resultsA total of 513 (44.22%) of 1160 had chronic PPI use; 371 met inclusion criteria and were evaluated: 285 (76.82%) with appropriate prescription and 86 (23.18%) with inappropriate, mainly (52.30%) due to polypharmacy. Seventy-five patients accepted the deprescribing process. Sixty-one (81.33%) maintained deprescription at week 4, 56 (74.66%) at week 12, and 54 (72.00%) at week 24. Eleven of 21 restarted the PPI because of symptoms. No differences were found between the successful deprescription group and the unsuccessful one, regarding sex (p = 0.877), age (p = 0.635), PPI indication (p = 0.663), or deprescription regimen (p = 0.805). No patient had any adverse event attributable to deprescription.
conclusionThere is a high inappropriate indication for PPIs in patients admitted to the gastroenterology department. The application of a patient-centered deprescribing algorithm is a safe and effective strategy to reduce their inappropriate consumption in the medium term.
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