Evidence map›Paper›PMID 34269719›Full record

ArticleCritical care medicine2021

Ischemic and Hemorrhagic Stroke Among Critically Ill Patients With Coronavirus Disease 2019: An International Multicenter Coronavirus Disease 2019 Critical Care Consortium Study.

Sung-Min Cho, Lavienraj Premraj, Jonathon Fanning, Samuel Huth, Adrian Barnett, Glenn Whitman, Rakesh C Arora, Denise Battaglini, Diego Bastos Porto, HuiMahn Choi and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  18. Nomogram for Risk of Secondary Venous Thromboembolism in Stroke Patients: A Study Based on the MIMIC-IV Database.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 6 countries.

Sung-Min ChoDivision of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Lavienraj PremrajGriffith University School of Medicine, Gold Coast, QLD, Australia.
Jonathon FanningCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Samuel HuthCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Adrian BarnettAustralian Centre for Health Services Innovation (AusHSI) and Centre for Healthcare Transformation, School of Public Health & Social Work, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
Glenn WhitmanDivision of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Rakesh C AroraDivision of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Denise BattagliniDepartment of Surgical Science and Integrated Diagnostic, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, University of Genoa, Genoa, Italy.
Diego Bastos PortoHospital Sao Camilo de Esteio, Esteio, Brazil.
HuiMahn ChoiUniversity of Texas Health Sciences Center, Houston, TX.
Jacky SuenCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Gianluigi Li BassiCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
John F FraserCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Chiara RobbaDepartment of Surgical Science and Integrated Diagnostic, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, University of Genoa, Genoa, Italy.
Matthew GriffeeDepartment of Anesthesiology, University of Utah, Salt Lake City, UT.
Prince Charles Hospital · AUUniversity of Genoa · ITUniversity of Queensland · AUUniversity of Utah · USConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESGriffith University · AUQueensland University of Technology · AUSão Camilo Hospital · BRThe University of Texas Health Science Center at Houston · US

Funding

CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) studyK23HL157610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Sung-Min Cho · 2022 to 2026
$797k
NHLBI NIH HHS K23 HL157610NHLBI NIH HHS L30 HL165486
6 · The paper itself

Abstract

objectivesStroke has been reported in observational series as a frequent complication of coronavirus disease 2019, but more information is needed regarding stroke prevalence and outcomes. We explored the prevalence and outcomes of acute stroke in an international cohort of patients with coronavirus disease 2019 who required ICU admission.

designRetrospective analysis of prospectively collected database.

settingA registry of coronavirus disease 2019 patients admitted to ICUs at over 370 international sites was reviewed for patients diagnosed with acute stroke during their stay. PATIENTS: Patients older than 18 years old with acute coronavirus disease 2019 infection in ICU.

interventionsNone. MEASUREMENTS AND MAIN

resultsOf 2,699 patients identified (median age 59 yr; male 65%), 59 (2.2%) experienced acute stroke: 0.7% ischemic, 1.0% hemorrhagic, and 0.5% unspecified type. Systemic anticoagulant use was not associated with any stroke type. The frequency of diabetes, hypertension, and smoking was higher in patients with ischemic stroke than in stroke-free and hemorrhagic stroke patients. Extracorporeal membrane oxygenation support was more common among patients with hemorrhagic (56%) and ischemic stroke (16%) than in those without stroke (10%). Extracorporeal membrane oxygenation patients had higher cumulative 90-day probabilities of hemorrhagic (relative risk = 10.5) and ischemic stroke (relative risk = 1.7) versus nonextracorporeal membrane oxygenation patients. Hemorrhagic stroke increased the hazard of death (hazard ratio = 2.74), but ischemic stroke did not-similar to the effects of these stroke types seen in noncoronavirus disease 2019 ICU patients.

conclusionsIn an international registry of ICU patients with coronavirus disease 2019, stroke was infrequent. Hemorrhagic stroke, but not ischemic stroke, was associated with increased mortality. Further, both hemorrhagic stroke and ischemic stroke were associated with traditional vascular risk factors. Extracorporeal membrane oxygenation use was strongly associated with both stroke and death.

Indexed as

AgedComorbidityCOVID-19Critical IllnessExtracorporeal Membrane OxygenationFemaleHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedRespiration, ArtificialRetrospective StudiesRisk FactorsSARS-CoV-2Stroke

Identifiers

PMID34269719
PMCPMC8594524
OpenAlexW3179223676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.