Evidence map›Paper›PMID 34269678›Full record

ArticleeLife2021

Homo-oligomerization of the human adenosine A

Khanh Dinh Quoc Nguyen, Michael Vigers, Eric Sefah, Susanna Seppälä, Jennifer Paige Hoover, Nicole Star Schonenbach, Blake Mertz, Michelle Ann O'Malley, Songi Han

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Tumor-Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Khanh Dinh Quoc NguyenDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0002-9367-499X
Michael VigersDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, United States.
Eric SefahC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, United States.
Susanna SeppäläDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, United States.
Jennifer Paige HooverDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, United States.
Nicole Star SchonenbachDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, United States.
Blake MertzC. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, United States.
Michelle Ann O'MalleyDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, United States.
Songi HanDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, United States.ORCID 0000-0001-6489-6246
University of California, Santa Barbara · USWest Virginia University · US

Funding

Water as essential building blocks to direct protein structure and functionR35GM136411 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han · 2020 to 2026
$2.4M
SHG based screening assay for detecting effectors of brain localized GPCRs that can be used to probe mental illness related phenotypesR43MH119906 · NIMH · BIODESY, INC · PI MOREE, BEN, O'MALLEY, MICHELLE ANN · 2019 to 2020
$541k
NIGMS NIH HHS R35 GM136411NIMH NIH HHS R43 MH119906
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) have long been shown to exist as oligomers with functional properties distinct from those of the monomeric counterparts, but the driving factors of oligomerization remain relatively unexplored. Herein, we focus on the human adenosine A

Indexed as

AdenosineEscherichia coliGene ExpressionHumansProtein ConformationReceptor, Adenosine A2AAdenosineADORA2A protein, humanReceptor, Adenosine A2Aadenosine a2a receptorbiochemistrychemical biologyc-terminusdepletion interactionsE. coligpcrsintrinsically disordered regionsmolecular biophysicsoligomerizationS. cerevisiaestructural biology

Identifiers

PMID34269678
PMCPMC8328514
OpenAlexW3179257742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.