Evidence map›Paper›PMID 34269138›Full record

ArticleEpigenetics2022

Hypermethylation of the oxytocin receptor gene (OXTR) in obsessive-compulsive disorder: further evidence for a biomarker of disease and treatment response.

Katharina Bey, Rafael Campos-Martin, Julia Klawohn, Benedikt Reuter, Rosa Grützmann, Anja Riesel, Michael Wagner, Alfredo Ramirez, Norbert Kathmann

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Epigenetic markers of response to psychotherapy in obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  15. Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katharina BeyDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-6392-4997
Rafael Campos-MartinDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Julia KlawohnDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Benedikt ReuterDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Rosa GrützmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Anja RieselDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Michael WagnerDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Alfredo RamirezDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Norbert KathmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Humboldt-Universität zu Berlin · DEUniversity Hospital Bonn · DEUniversity of Cologne · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) has recently been linked to increased methylation levels in the oxytocin receptor (

Indexed as

DNA MethylationObsessive-Compulsive DisorderReceptors, OxytocinBiomarkersHumansOxytocinBiomarkersOXTR protein, humanOxytocinReceptors, OxytocinepigeneticmethylationObsessive-compulsive disorderOXTRtreatment response

Identifiers

PMID34269138
PMCPMC9235899
OpenAlexW3183123502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.