ArticleJournal of biomedical optics2021
Irradiance uniformity optimization for a photodynamic therapy treatment device with 3D scanner.
Article in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Peptide-Guided Photodynamic Therapy via Integrin αvβ6 in Pancreatic Cancer.International journal of molecular sciences · 2026Article
- Artificial intelligence-assisted photodynamic diagnosis and photodynamic therapy against cancer.Frontiers in oncology · 2026Review
- Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends.Cancers · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceThe light dose in photodynamic therapy (PDT) has a considerable influence on its treatment effect, and irradiance uniformity is an issue of much concern for researchers. However, achieving intelligent and personalized dosimetry adjustments remains a challenge for current PDT instruments.
aimTo meet the requirements of intelligent and personalized dosimetry adjustments for the light dose on an irregular surface, a new PDT device with its optimal control method is proposed. APPROACH: This research introduces a new PDT device that includes a 3D scanner, a light-emitting diode (LED) array, and a computer. The 3D scanner is proposed to generate the point cloud of the lesion and the LED array light source, and obtain the relative position and rotation parameters between them. Then, an image segmentation algorithm is used to segment the lesion point cloud into several cluster regions. Last, the current of each LED unit is adjusted separately to achieve the expected irradiance on each cluster.
resultsCompared with the general light source, the optimized light source increases the effective irradiance area by 9% to 15% and improves its uniformity by ∼9 % on a human port-wine stain head model.
conclusionsThe device and its optimal method may be used for optimizing the light dosimetry to realize intelligent and personalized treatment.
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Registered trials
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