Evidence map›Paper›PMID 34269011›Full record

ArticleJournal of Zhejiang University. Science. B2021

Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response.

Yuhua Liu, Xiaopeng Wan, Yuan Yuan, Jingjing Huang, Yijia Jiang, Kaiyue Zhao, Yan Wang, Yang Liu, Qingqing Wang, Hongchuan Jin

Open access · greenAbstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. The role of miRNAs in Behçet's disease.Frontiers in immunology · 2023
    Review
  11. Article
  12. The Functional Mechanism of MicroRNA in Oral Lichen Planus.Journal of inflammation research · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuhua LiuLaboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310016, China.
Xiaopeng WanInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yuan YuanDepartment of Clinical Laboratory, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Jingjing HuangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yijia JiangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Kaiyue ZhaoDepartment of Radiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Yan WangDepartment of Clinical Laboratory, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Yang LiuInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Qingqing WangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Hongchuan JinLaboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310016, China.
Zhejiang University · CNAffiliated Hospital of Hangzhou Normal University · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although microRNA-155 (miR-155) is considered a pro-inflammatory mediator, cumulative evidence indicates that it also has anti-inflammatory effects in macrophages and dendritic cells. In this study, we identified the dramatic expression changes of more than half of potential miR-155-targeted genes upon lipopolysaccharide (LPS) stimulation; 223 genes were down-regulated and 85 genes were up-regulated, including suppressor of cytokine signaling 1 (

Indexed as

3' Untranslated RegionsAdaptor Proteins, Signal TransducingAnimalsDendritic CellsEndotoxinsEndotoxin ToleranceImmunity, InnateInflammationLipopolysaccharidesMacrophagesMiceMicroRNAsRAW 264.7 CellsSignal TransductionSuppressor of Cytokine Signaling 1 ProteinToll-Like Receptor 43' Untranslated RegionsAdaptor Proteins, Signal TransducingEndotoxinsLipopolysaccharidesMicroRNAsMirn155 microRNA, mouseSocs1 protein, mouseSuppressor of Cytokine Signaling 1 ProteinTab2 protein, mouseTlr4 protein, mouseToll-Like Receptor 4Endotoxin toleranceMicroRNA-155 (miR-155)Suppressor of cytokine signaling 1 (SOCS1)Toll-like receptor 4 (TLR4)Transforming growth factor-β-activated kinase 1-binding protein 2 (TAB2)

Identifiers

PMID34269011
PMCPMC8284089
OpenAlexW3180558805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.