Evidence map›Paper›PMID 34268875›Full record

ArticleChemMedChem2021

Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase.

Rolf Büssing, Bianka Karge, Petra Lippmann, Peter G Jones, Mark Brönstrup, Ingo Ott

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Binding of Tetrachloroaurate(III) to Bovine or Human γ-Globulins.International journal of molecular sciences · 2026
    Article
  3. Modulating the microbiome as an approach to anticancer drug development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. N-Heterocyclic Carbenes as Ligands toJournal of medicinal chemistry · 2025
    Article
  7. Article
  8. Antibacterial and Anti-Influenza Activities ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  9. Article
  10. An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Geometry and UV-Vis Spectra of AuInternational journal of molecular sciences · 2023
    Article
  15. Article
  16. Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rolf BüssingInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106, Braunschweig, Germany.
Bianka KargeDepartment of Chemical Biology, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), Inhoffenstrasse 7, 38124, Braunschweig, Germany.
Petra LippmannInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106, Braunschweig, Germany.
Peter G JonesInstitute of Inorganic and Analytical Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106, Braunschweig, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), Inhoffenstrasse 7, 38124, Braunschweig, Germany.ORCID 0000-0002-8971-7045
Ingo OttInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106, Braunschweig, Germany.ORCID 0000-0002-8087-4618
Technische Universität Braunschweig · DEHelmholtz Centre for Infection Research · DE

Funding

DFG 382040922
6 · The paper itself

Abstract

A series of (NHC)Au(I)Cl monocarbene complexes and their gold(III) analogues (NHC)Au(III)Cl

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorEnzyme InhibitorsGoldGram-Negative BacteriaGram-Positive BacteriaHeterocyclic CompoundsHumansMethaneMicrobial Sensitivity TestsMolecular StructureAnti-Bacterial AgentsAntineoplastic AgentscarbeneEnzyme InhibitorsGoldHeterocyclic CompoundsMethaneThioredoxin-Disulfide ReductaseantibacterialgoldN-heterocyclic carbenethioredoxin reductase

Identifiers

PMID34268875
PMCPMC9290826
OpenAlexW3182493027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.