Evidence map›Paper›PMID 34268844›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases.

Oleg Babii, Sergii Afonin, Christian Diel, Marcel Huhn, Jennifer Dommermuth, Tim Schober, Serhii Koniev, Andrii Hrebonkin, Alexander Nesterov-Mueller, Igor V Komarov and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. A Urease-Based pH Photoswitch: A General Route to Light-to-pH Transduction.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Cystine Knot Peptides with Tuneable Activity and Mechanism.Angewandte Chemie (International ed. in English) · 2022
    Article
  9. Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases.Angewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Oleg BabiiInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany.ORCID 0000-0001-7107-1402
Sergii AfoninInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany.ORCID 0000-0002-2356-4226
Christian DielInstitute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Marcel HuhnInstitute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Jennifer DommermuthInstitute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Tim SchoberInstitute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.ORCID 0000-0003-3003-6816
Serhii KonievTaras Shevchenko National University of Kyiv, vul. Volodymyrska 60, 1601, Kyiv, Ukraine.ORCID 0000-0002-1292-9429
Andrii HrebonkinInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany.
Alexander Nesterov-MuellerInstitute of Microstructure Technology (IMT), KIT, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.ORCID 0000-0001-8446-2728
Igor V KomarovTaras Shevchenko National University of Kyiv, vul. Volodymyrska 60, 1601, Kyiv, Ukraine.ORCID 0000-0002-7908-9145
Anne S UlrichInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021, Karlsruhe, Germany.ORCID 0000-0001-5571-9483
Karlsruhe Institute of Technology · DETaras Shevchenko National University of Kyiv · UAApplied Materials (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A bicyclic peptide scaffold was chemically adapted to generate diarylethene-based photoswitchable inhibitors of serine protease Bos taurus trypsin 1 (T1). Starting from a prototype molecule-sunflower trypsin inhibitor-1 (SFTI-1)-we obtained light-controllable inhibitors of T1 with K

Indexed as

AnimalsCattleEthylenesMolecular StructurePeptides, CyclicSerine ProteasesSerine Proteinase InhibitorsethyleneEthylenesPeptides, CyclicSerine ProteasesSerine Proteinase Inhibitorsbicyclic peptidediarylethene photoswitchhydrogel photoregulationserine protease inhibitorstrypsin

Identifiers

PMID34268844
PMCPMC8519022
OpenAlexW3177800246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.