ReviewEuropean journal of heart failure2021
The ergoreflex: how the skeletal muscle modulates ventilation and cardiovascular function in health and disease.
Review in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- The effects of inspiratory muscle training on respiratory function and aerobic capacity in sedentary adolescents: A single-blind randomized controlled trial.Scientific reports · 2026Trial
- Acute right-sided transcutaneous vagus nerve stimulation improves cardio-vagal baroreflex gain in patients with chronic heart failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Trial
- Effect of a new resistance training method on the metaboreflex in cardiac rehabilitation patients: a randomized controlled trial.European journal of applied physiology · 2024Trial
- The effect of blood flow-restrictive resistance training on the risk of atherosclerotic cardiovascular disease in middle-aged patients with type 2 diabetes: a randomized controlled trial.Frontiers in endocrinology · 2024Trial
- The Need for Breathing Training Techniques: The Elephant in the Heart Failure Cardiac Rehabilitation Room: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Skeletal Muscle Strength in Patients on the Heart Transplant Waiting List: Are There Any Associations with Instrumental Examination Data?Journal of clinical medicine · 2026Article
- Context-dependent regulation of IL-6 in exercise and colorectal cancer cachexia.Frontiers in oncology · 2026Review
- Resting-state functional connectivity changes in the human brain from electrically-stimulated (2 Hz), rhythmic muscle contractions to the hand: An exploratory study.Neuroimage. Reports · 2025Article
- Combinations of predictors of exercise-induced oxygen desaturation after lung resection: a retrospective observational study.Journal of thoracic disease · 2025Article
- Mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF).Heart failure reviews · 2025Review
- Heart and brain interactions in heart failure: pathophysiological mechanisms and clinical perspectives.Heart failure reviews · 2025Review
- Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance.Journal of the American Heart Association · 2025Review
- Periodic breathing during exercise in heart failure: beyond the classic risk factors.European heart journal supplements : journal of the European Society of Cardiology · 2025Article
- Epigenetic factors and inflammaging: FOXO3A as a potential biomarker of sarcopenia and upregulation of DNMT3A and SIRT3 in older adults.Frontiers in immunology · 2025Article
- The chronobiology of human heart failure: clinical implications and therapeutic opportunities.Heart failure reviews · 2025Review
- Impact of chest computed tomography-determined low skeletal muscle mass on the survival of patients with acute heart failure.Frontiers in cardiovascular medicine · 2025Article
- Cancer Therapy and Exercise Intolerance: The Heart Is But a Part:JACC. CardioOncology · 2024Review
- Influence of blood lactate variations and passive exercise on cardiac responses.Journal of physical therapy science · 2024Article
- Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case-control study.Frontiers in physiology · 2024Article
- Consequences of group III/IV afferent feedback and respiratory muscle work on exercise tolerance in heart failure with reduced ejection fraction.Experimental physiology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control of ventilation and cardiovascular function during physical activity is partially regulated by the ergoreflex, a cardiorespiratory reflex activated by physical activity. Two components of the ergoreflex have been identified: the mechanoreflex, which is activated early by muscle contraction and tendon stretch, and the metaboreflex, which responds to the accumulation of metabolites in the exercising muscles. Patients with heart failure (HF) often develop a skeletal myopathy with varying degrees of severity, from a subclinical disease to cardiac cachexia. HF-related myopathy has been associated with increased ergoreflex sensitivity, which is believed to contribute to dyspnoea on effort, fatigue and sympatho-vagal imbalance, which are hallmarks of HF. Ergoreflex sensitivity increases significantly also in patients with neuromuscular disorders. Exercise training is a valuable therapeutic option for both HF and neuromuscular disorders to blunt ergoreflex sensitivity, restore the sympatho-vagal balance, and increase tolerance to physical exercise. A deeper knowledge of the mechanisms mediating ergoreflex sensitivity might enable a drug or device modulation of this reflex when patients cannot exercise because of advanced skeletal myopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.