ArticleMagnetic resonance in medicine2021
In vivo macromolecule signals in rat brain
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T.Magma (New York, N.Y.) · 2026Article
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- MRS-Sim: Open-Source Framework for Simulating In Vivo-Like Magnetic Resonance Spectra.NMR in biomedicine · 2025Article
- Macromolecule Modelling for Improved Metabolite Quantification Using Short Echo Time BrainNMR in biomedicine · 2025Article
- PyAMARES, an Open-Source Python Library for Fitting Magnetic Resonance Spectroscopy Data.Diagnostics (Basel, Switzerland) · 2024Article
- Model-based frequency-and-phase correction ofMagnetic resonance in medicine · 2024Article
- High-resolutionNMR in biomedicine · 2024Article
- GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling?Magnetic resonance in medicine · 2024Article
- Model-based frequency-and-phase correction ofbioRxiv : the preprint server for biology · 2024Article
- Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy.Nature communications · 2024Article
- Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel.NMR in biomedicine · 2024Article
- Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study.Frontiers in neuroscience · 2024Article
- Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset.Metabolic brain disease · 2023Article
- In vivo magnetic resonance spectroscopy by transverse relaxation encoding with narrowband decoupling.Scientific reports · 2023Article
- Article
- The macromolecular MR spectrum does not change with healthy aging.Magnetic resonance in medicine · 2022Article
- In vivo macromolecule signals in rat brainMagnetic resonance in medicine · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
purposeReliable detection and fitting of macromolecules (MM) are crucial for accurate quantification of brain short-echo time (TE)
methodsA single inversion recovery sequence combined with advanced AMARES prior knowledge was used to eliminate the metabolite residuals, fit, and parametrize 10 MM components directly from 9.4T rat brain in vivo
resultsA very stiff baseline (DKNTMN ≥ 1 ppm) in combination with a single MM spectrum led to deviations in metabolite concentrations. For some metabolites the parametrized MM showed deviations from the ground truth for all DKNTMN values. Adding prior knowledge on parametrized MM improved MM and metabolite quantification. The apparent T
conclusionModerate flexibility in the spline baseline was required for reliable quantification of real/experimental spectra based on in vivo and Monte Carlo data. Prior knowledge on parametrized MM improved MM and metabolite quantification.
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