Evidence map›Paper›PMID 34268729›Full record

ArticleBritish journal of haematology2021

Biomarkers of clinical severity in treated and untreated sickle cell disease: a comparison by genotypes of a single center cohort and African Americans in the NHANES study.

Franklin Njoku, Xu Zhang, Binal N Shah, Roberto F Machado, Jin Han, Santosh L Saraf, Victor R Gordeuk

Open access · greenAbstract readComparative Study
In one paragraph

Article in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Associations of hemolysis and anemia with cardiopulmonary dysfunction in an adult sickle cell disease cohort.Clinica chimica acta; international journal of clinical chemistry · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Franklin NjokuDivision of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0003-4171-3202
Xu ZhangDivision of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA.
Binal N ShahDivision of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA.
Roberto F MachadoDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN, USA.
Jin HanDepartment of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0003-0662-006X
Santosh L SarafDivision of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0002-8584-4194
Victor R GordeukDivision of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0003-4725-7295
University of Illinois Chicago · USIndiana University Indianapolis · US

Funding

Vascular Targeting Genomic & Genetic Strategies for Acute Chest SyndromeR01HL111656 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Roberto F. Machado · 2013 to 2026
$7.9M
Pathways of Cell-Free Hemoglobin in Sickle Cell NephropathyR01HL153161 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARAF, SANTOSH · 2020 to 2024
$2.0M
NHLBI NIH HHS R01 HL111656NHLBI NIH HHS R01 HL153161
6 · The paper itself

Abstract

Haemolysis and vaso-occlusion underlie multi-organ system complications in sickle cell disease (SCD). We assessed real-world biomarkers in University of Illinois adult SCD patients, categorised as severe (HbSS/Sβ

Indexed as

AdultAnemia, Sickle CellAntisickling AgentsBlack or African AmericanBlood TransfusionCross-Sectional StudiesFemaleGenotypeHumansHydroxyureaMaleSeverity of Illness IndexYoung AdultAntisickling AgentsHydroxyureabiomarkerNHANESSCD genotypeSCD phenotypesickle cell disease

Identifiers

PMID34268729
PMCPMC8373676
OpenAlexW3179620480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.