Evidence map›Paper›PMID 34268681›Full record

ArticleLa Radiologia medica2021

Breast cancer patient perspective on opportunities and challenges of a genetic test aimed to predict radio-induced side effects before treatment: Analysis of the Italian branch of the REQUITE project.

Lara Bellardita, Riccardo Ray Colciago, Sarah Frasca, Maria Carmen De Santis, Simona Gay, Federica Palorini, Eliana La Rocca, Riccardo Valdagni, Tiziana Rancati, Laura Lozza

Abstract read
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In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Gender Medicine in Clinical Radiology Practice.Journal of personalized medicine · 2023
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  11. Immunotherapy Assessment: A New Paradigm for Radiologists.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lara BellarditaProstate Cancer Program, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Riccardo Ray ColciagoDepartment of Radiotherapy, Università Degli Studi Di Milano Bicocca, Milan, Italy.
Sarah FrascaRadiation Oncology 1 Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Maria Carmen De SantisRadiation Oncology 1 Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy. MariaCarmen.DeSantis@istitutotumori.mi.it.
Simona GayProstate Cancer Program, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Federica PaloriniProstate Cancer Program, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Eliana La RoccaRadiation Oncology 1 Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Riccardo ValdagniProstate Cancer Program, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Tiziana Rancati *Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Laura Lozza *Radiation Oncology 1 Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore breast cancer patient's perspective on future genetic testing for prediction of toxicity after breast radiotherapy (RT). MATERIALS AND

methodsThe study involved patient enrolled in the Italian branch of the REQUITE project conducted at the National Cancer Institute in Milan. Semi-structured interviews were conducted within one month from the end of radiotherapy treatment by two radiation oncologists and a radiotherapy technician previously trained by a clinical psychologist with experience in the oncology field. Semi-structured interviews are characterized by a set of pre-defined questions and developed ad hoc by researchers in Leicester within the REQUITE project. The interview questions investigated interest in undergoing the genetic test and expectations on its usefulness and disadvantages.

resultsEighteen interviews were conducted and analysed. Forty-five initial codes were combined into nine themes which were then clustered in two main macro-areas (i) Opportunities and (ii) Challenges. Overall, all patients understand the aim of the genetic test and considered its intrinsic opportunity to make the physician more confident with the treatment. Regarding side effects, most of patients felt prepared to RT but not without fear. Many women considered important to have the largest and reliable information, also about negative experiences. Prevailing emotions were anxiety and fear but not connected to genetic test's result.

conclusionsA genetic test could be an opportunity because generate knowledge and give patients a dynamic role in the decision-making approach. Prediction of single patient radiosensitivity before RT could prompt suggestion to entail a more and more tailored radiation treatment in the era of personalized approach.

Indexed as

AdultAgedBreast NeoplasmsFemaleGenetic TestingHumansInterviews as TopicItalyMiddle AgedPatientsPredictive Value of TestsRadiation ToleranceSurveys and QuestionnairesBreast cancerGenetic testRadiotherapy toxicitySemi-structured interviews

Identifiers

PMID34268681
OpenAlexW3177783497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.