Evidence map›Paper›PMID 34268655›Full record

ArticleNeurochemical research2021

SRC-3 Deficiency Exacerbates Neurological Deficits in a Mouse Model of Intracerebral Hemorrhage: Role of Oxidative Stress.

Mingyang Deng, Jianyang Liu, Jialin He, Ziwei Lan, Zhiping Hu, Huan Yuan, Han Xiao

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mingyang DengDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.ORCID http://orcid.org/0000-0001-6974-388X
Jianyang LiuDepartment of Neurology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha, 410011, Hunan, China.ORCID http://orcid.org/0000-0001-6826-027X
Jialin HeDepartment of Neurology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha, 410011, Hunan, China.ORCID http://orcid.org/0000-0002-6135-2638
Ziwei LanDepartment of Neurology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha, 410011, Hunan, China.ORCID http://orcid.org/0000-0003-4495-1740
Zhiping HuDepartment of Neurology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha, 410011, Hunan, China.ORCID http://orcid.org/0000-0001-5672-9683
Huan YuanDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.ORCID http://orcid.org/0000-0003-3621-7968
Han XiaoDepartment of Neurology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha, 410011, Hunan, China. xiaohan1016@csu.edu.cn.ORCID http://orcid.org/0000-0002-9606-7028
Central South University · CN

Funding

National Natural Science Foundation of China 81801188Natural Science Foundation of Hunan Province 2019JJ40421
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) causes long term neurological abnormality or death. Oxidative stress is closely involved in ICH mediated brain damage. Steroid receptor cofactor 3 (SRC-3), a p160 family member, is widely expressed in the brain and regulates transactivation of Nrf2, a key component of antioxidant response. Our study aims to test if SRC-3 is implicated in ICH mediated brain injury. We first examined levels of SRC-3 and oxidative stress in the brain of mice following ICH and analyzed their correlation. Then ICH was induced in wild type (WT) and SRC-3 knock out mice and how SRC-3 deletion affected ICH induced brain damage, oxidative stress and behavioral outcome was assessed. We found that SRC-3 mRNA and protein expression levels were reduced gradually after ICH induction in WT mice along with an increase in oxidative stress levels. Correlation analysis revealed that SRC-3 mRNA levels negatively correlated with oxidative stress. Deletion of SRC-3 further increased ICH induced brain edema, neurological deficit score and oxidative stress and exacerbated ICH induced behavioral abnormality including motor dysfunction and cognitive impairment. Our findings suggest that SRC-3 is involved in ICH induced brain injury, probably through modulation of oxidative stress.

Indexed as

Disease Models, AnimalAnimalsCerebral HemorrhageMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutNervous System DiseasesNuclear Receptor Coactivator 3Oxidative StressNcoa3 protein, mouseNuclear Receptor Coactivator 3Brain damageNeurological deficitSecondary brain injurySRC-3 deficiencyStroke

Identifiers

PMID34268655
OpenAlexW3181539465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.