ArticleJournal of gastroenterology2021
Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type.
Article in Journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 62 citations in OpenAlex.
- Feasibility and safety of cap-assisted endoscopic mucosal resection compared with endoscopic submucosal dissection for gastric adenocarcinoma of the fundic gland type.Surgical endoscopy · 2026Article
- Transformation From Oxyntic Gland Neoplasm Into Advanced Gastric Cancer viaJournal of medical cases · 2026Article
- Gastric Epithelial Neoplasms with Fundic Gland Mucosa Lineage - Size and Morphology Correlate Well with Tumor Depth.Internal medicine (Tokyo, Japan) · 2026Article
- Clinicopathological characterization of extremely low-grade fundic gland tumors: a study of 11 of a variant of oxyntic gland adenomas.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Gastric sarcoidosis presenting as multiple, discolored mucosal lesions after Helicobacter pylori eradication.Clinical journal of gastroenterology · 2026Article
- Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges.International journal of cancer · 2026Review
- Gastric Adenomas and Mimickers: A Review.Diagnostics (Basel, Switzerland) · 2026Review
- Long-term outcomes after endoscopic resection of gastric adenocarcinoma of the fundic gland type and oxyntic gland adenoma: a retrospective cohort study.Scientific reports · 2026Article
- An emerging entity of gastric adenocarcinoma: clinicopathological features and differential diagnosis of gastric adenocarcinoma of fundic-gland type in 25 retrospective cases.Virchows Archiv : an international journal of pathology · 2026Article
- <italic>Helicobacter pylori</italic>-Naïve Gastric Neoplasms: Clinicopathological and Molecular Features and Diagnostic Challenges.Digestion · 2026Review
- Gastric Epithelial Neoplasms in <italic>Helicobacter pylori</italic>-Uninfected Patients.Digestion · 2026Review
- Recognizing Gastric Oxyntic Gland Neoplasms: Characteristic Endoscopic Appearance for Improved Detection.Endoscopy international open · 2026Article
- A case presentation of duodenal gastric epithelial neoplasm-fundic-gland mucosa lesions.Endoscopy · 2025Article
- Comparative Analysis of Gastric Epithelial Neoplasm of Fundic-Gland Mucosa Lineage: Histopathological Features of Background Gastric Mucosa.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Genomic and transcriptomic landscape of carcinogenesis in patients with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS).Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Gastric adenocarcinoma with submucosal invasion occurs in a sporadic fundic gland polyp of a Helicobacter pylori-uninfected patient on proton pump inhibitor.Clinical journal of gastroenterology · 2025Article
- A case of multiple gastric adenocarcinoma of fundic gland type accidentally found by additional gastrectomy following endoscopic submucosal dissection.International cancer conference journal · 2025Article
- Visibility evaluation of gastric epithelial neoplasm of fundic gland mucosa lineage using texture and color enhancement imaging.DEN open · 2025Article
- Contract to kill: GNAS mutation.Molecular cancer · 2025Review
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Authors and funding
41 authors at 20 institutions in 1 country.
Funding
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Abstract
backgroundGastric adenocarcinoma of fundic-gland type (GA-FG) is a rare variant of gastric neoplasia. However, the etiology, classification, and clinicopathological features of gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML; generic term of GA-FG related neoplasm) are not fully elucidated. We performed a large, multicenter, retrospective study to establish a new classification and clarify the clinicopathological features of GEN-FGML.
methodsOne hundred GEN-FGML lesions in 94 patients were collected from 35 institutions between 2008 and 2019. We designed a new histopathological classification of GEN-FGML using immunohistochemical analysis and analyzed via clinicopathological, immunohistochemical, and genetic evaluation.
resultsGEN-FGML was classified into 3 major types; oxyntic gland adenoma (OGA), GA-FG, and gastric adenocarcinoma of fundic-gland mucosa type (GA-FGM). In addition, GA-FGM was classified into 3 subtypes; Type 1 (organized with exposure type), Type 2 (disorganized with exposure type), and Type 3 (disorganized with non-exposure type). OGA and GA-FG demonstrated low-grade epithelial neoplasm, and GA-FGM should be categorized as an aggressive variant of GEN-FGML that demonstrated high-grade epithelial neoplasm (Type 2 > 1, 3). The frequent presence of GNAS mutation was a characteristic genetic feature of GEN-FGML (7/34, 20.6%; OGA 1/3, 33.3%; GA-FG 3/24, 12.5%; GA-FGM 3/7, 42.9%) in mutation analysis using next-generation sequencing.
conclusionsWe have established a new histopathological classification of GEN-FGML and propose a new lineage of gastric epithelial neoplasm that harbors recurrent GNAS mutation. This classification will be useful to estimate the malignant potential of GEN-FGML and establish an appropriate standard therapeutic approach.
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