ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022
Association between exposure to fine particulate matter and osteoporosis: a population-based cohort study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 44 citations in OpenAlex.
- Osteoporosis: molecular pathogenesis and therapeutic interventions.Molecular biomedicine · 2025Review
- Review
- Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women's Health Initiative participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Associations between blood ethylene oxide levels and bone mineral density.Frontiers in public health · 2025Article
- Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province.Scientific reports · 2024Article
- Air Pollution and Osteoporosis.Current osteoporosis reports · 2024Review
- Prevalence Characteristics of Osteoporosis Fractures in the Elderly in Two Regions of China and Analysis of the Lag Effect of Air Pollutants on them.Orthopaedic surgery · 2024Article
- Osteogenic Protection against Fine Dust with Erucic Acid-Induced Exosomes.Journal of functional biomaterials · 2024Article
- Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases.Nature reviews. Rheumatology · 2024Review
- Role of active and environmental tobacco smoke on susceptibility to osteoporosis in women undergoing dual-X-ray absorptiometry.Journal of endocrinological investigation · 2024Article
- Long-term air pollution and adverse meteorological factors might elevate the osteoporosis risk among adult Chinese.Frontiers in public health · 2024Article
- Potential causal associations of PM2.5 and osteoporosis: a two-sample mendelian randomization study.Frontiers in genetics · 2024Article
- Association between air pollution and bone mineral density: a Mendelian randomization study.Archives of medical science : AMS · 2024Article
- Article
- Exposure to Neighborhood Walkability and Residential Greenness and Incident Fracture.JAMA network open · 2023Article
- Long-Term Exposure to PMToxics · 2023Article
- Air pollution and decreased bone mineral density among Women's Health Initiative participants.EClinicalMedicine · 2023Article
- Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank.Frontiers in public health · 2023Article
- Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment.RMD open · 2022Article
- Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study.RMD open · 2022Observational
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Authors and funding
10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Long-term environmental air pollution exposure was associated with osteoporosis' risk in a cohort of women at high risk of fracture. Cortical sites seemed to be more susceptible to the exposure's effect.
introductionEnvironmental air pollution has been associated with disruption of bone health at a molecular level. Particulate matter (PM) exposure can simultaneously stimulate bone resorption and halt bone formation. The primary aim of the present study is to describe the association between long-term exposure to PM and osteoporosis in a large cohort of women at high risk of fracture.
methodsClinical, demographic, and densitometric data were extracted from the DeFRAcalc79 dataset, which gathers data on women at risk for osteoporosis. Data on the monitoring of PM10 and PM2.5 concentrations were retrieved from the Italian institute of environment protection and research (Istituto Superiore per la Protezione e la Ricerca Ambientale, ISPRA). Generalized linear models with robust estimators were employed to determine the relationship between BMD and PM long-term exposure.
resultsA total 59,950 women from 110 Italian provinces were included in the study. PM 2.5 exposure was negatively associated with T-score levels at the femoral neck (β -0.005, 95 CI -0.007 to -0.003) and lumbar spine (β -0.003, 95% CI -0.006 to -0.001). Chronic exposure to PM2.5 above 25 μg/m
conclusionLong-term exposure to air pollution was associated with higher risk of osteoporosis. Femoral neck site seemed to be more susceptible to the detrimental effect of PM exposure than lumbar spine site. KEY MESSAGE: Exposure to air pollution is associated with osteoporosis, mainly at femoral site.
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