Evidence map›Paper›PMID 34268586›Full record

ArticlePsychopharmacology2021

Vulnerability factors for mephedrone-induced conditioned place preference in rats-the impact of sex differences, social-conditioning and stress.

Olga Wronikowska, Maria Zykubek, Łukasz Kurach, Agnieszka Michalak, Anna Boguszewska-Czubara, Barbara Budzyńska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Olga WronikowskaChair and Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a street, 20-093, Lublin, Poland.
Maria ZykubekIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4a street, 20-093, Lublin, Poland.
Łukasz KurachIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4a street, 20-093, Lublin, Poland.
Agnieszka MichalakIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4a street, 20-093, Lublin, Poland.
Anna Boguszewska-CzubaraChair and Department of Medical Chemistry, Medical University of Lublin, Chodzki 4a street, 20-093, Lublin, Poland.
Barbara BudzyńskaIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4a street, 20-093, Lublin, Poland. barbarabudzynska@umlub.pl.
Medical University of Lublin · PL

Funding

Narodowym Centrum Nauki 2017/25/B/NZ7/02410
6 · The paper itself

Abstract

rationaleMephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of action, as well as toxic and psychoactive effects, has been widely studied, the role of different factors that could contribute to the increased vulnerability to mephedrone abuse is still poorly understood.

objectivesThe aim of the presented study was to assess the impact of several factors (sex differences, social-conditioning, and chronic mild unpredictable stress - CMUS) on the liability to mephedrone-induced reward in Wistar rats.

methodsThe rewarding effects of mephedrone in male and female rats were assessed using the conditioned place preference (CPP) procedure. Furthermore, the impact of social factor and stress was evaluated in male rats using social-CPP and CMUS-dependent CPP, respectively.

resultsMephedrone induced classic-CPP in female (10 mg/kg), as well as in male (10 and 20 mg/kg) rats. However, the impact of mephedrone treatment during social-CPP was highly dose-dependent as the rewarding effects of low dose of mephedrone (5 mg/kg; non-active in classic-CPP) were potentiated when administered during social-conditioning. Interestingly, social-conditioning with a higher dose of 20 mg/kg (that induced classic-CPP) was able to reverse these effects. Finally, CMUS potentiated rewarding effects of a low dose of mephedrone (5 mg/kg) and increased the level of corticosterone in rats' prefrontal cortex and hippocampus.

conclusionsAltogether, the presented results give new insight into possible factors underlying the vulnerability to mephedrone abuse and can serve as a basis for further studies assessing mechanisms underlying observed effects.

Indexed as

MethamphetamineSex CharacteristicsAnimalsConditioning, ClassicalFemaleMaleRatsRats, WistarRewardmephedroneMethamphetamineCorticosteroneMephedroneRewardSexSocial interactionsStress

Identifiers

PMID34268586
PMCPMC8455394
OpenAlexW3178083667

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.