Evidence map›Paper›PMID 34268526›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Anxiety and depression symptoms after COVID-19 infection: results from the COVID Symptom Study app.

Kerstin Klaser, Ellen J Thompson, Long H Nguyen, Carole H Sudre, Michela Antonelli, Benjamin Murray, Liane S Canas, Erika Molteni, Mark S Graham, Eric Kerfoot and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 17 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 2 countries.

Kerstin KlaserSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Ellen J ThompsonDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Long H NguyenClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, USA.
Carole H SudreSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Michela AntonelliSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Benjamin MurraySchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Liane S CanasSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Erika MolteniSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Mark S GrahamSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Eric KerfootSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Liyuan ChenSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Jie DengSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Anna MayZoe Limited, London SE1 7RW, UK.
Christina HuZoe Limited, London SE1 7RW, UK.
Andy GuestZoe Limited, London SE1 7RW, UK.
Somesh SelvachandranZoe Limited, London SE1 7RW, UK.
David A DrewClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, USA.
Marc ModatSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Andrew T ChanClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, USA.
Jonathan WolfZoe Limited, London SE1 7RW, UK.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Alexander HammersSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Emma L DuncanDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Sebastien OurselinSchool of Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EU, UK.
Claire J StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
King's College London · GBZOE (United Kingdom) · GBHarvard University · US

Funding

Dietary strategies for rational manipulation of the gut microbiome in inflammatory bowel diseaseK23DK125838 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, LONG H · 2020 to 2024
$1.0M
Impact of Aspirin on the Gut Microbiome and Mucosal MicroenvironmentK01DK120742 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DREW, DAVID A · 2020 to 2024
$793k
EPA EP-W-17-011Medical Research Council MC_PC_20030NIDDK NIH HHS K01 DK120742NIDDK NIH HHS K23 DK125838Wellcome Trust
6 · The paper itself

Abstract

backgroundMental health issues have been reported after SARS-CoV-2 infection. However, comparison to prevalence in uninfected individuals and contribution from common risk factors (e.g., obesity, comorbidities) have not been examined. We identified how COVID-19 relates to mental health in the large community-based COVID Symptom Study.

methodsWe assessed anxiety and depression symptoms using two validated questionnaires in 413,148 individuals between February and April 2021; 26,998 had tested positive for SARS-CoV-2. We adjusted for physical and mental pre-pandemic comorbidities, BMI, age, and sex.

findingsOverall, 26.4% of participants met screening criteria for general anxiety and depression. Anxiety and depression were slightly more prevalent in previously SARS-CoV-2 positive (30.4%) vs. negative (26.1%) individuals. This association was small compared to the effect of an unhealthy BMI and the presence of other comorbidities, and not evident in younger participants (≤40 years). Findings were robust to multiple sensitivity analyses. Association between SARS-CoV-2 infection and anxiety and depression was stronger in individuals with recent (<30 days) vs. more distant (>120 days) infection, suggesting a short-term effect.

interpretationA small association was identified between SARS-CoV-2 infection and anxiety and depression symptoms. The proportion meeting criteria for self-reported anxiety and depression disorders is only slightly higher than pre-pandemic.

fundingZoe Limited, National Institute for Health Research, Chronic Disease Research Foundation, National Institutes of Health, Medical Research Council UK.

Identifiers

PMID34268526
PMCPMC8282115
OpenAlexW3181140384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.