ArticleFrontiers in big data2021
Holdout-Based Empirical Assessment of Mixed-Type Synthetic Data.
Article in Frontiers in big data, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A case study comparing anonymized and synthetic health insurance claims data for medication safety assessments.NPJ digital medicine · 2026Article
- Generative AI models for type 2 diabetes mellitus risk prediction.Health systems (Basingstoke, England) · 2026Article
- A call for principle-based acceptance of synthetic patients: establishing the AI-driven foundation for regulatory submissions.Frontiers in digital health · 2026Review
- A consensus privacy metrics framework for synthetic data.Patterns (New York, N.Y.) · 2025Article
- A scoping review of privacy and utility metrics in medical synthetic data.NPJ digital medicine · 2025Article
- Large language models generating synthetic clinical datasets: a feasibility and comparative analysis with real-world perioperative data.Frontiers in artificial intelligence · 2025Article
- Anonymize or synthesize? Privacy-preserving methods for heart failure score analytics.European heart journal. Digital health · 2025Article
- Decades in the Making: The Evolution of Digital Health Research Infrastructure Through Synthetic Data, Common Data Models, and Federated Learning.Journal of medical Internet research · 2024Article
- Synthesis and quality assessment of combined time-series and static medical data using a real-world time-series generative adversarial network.Scientific reports · 2024Article
- An evaluation of the replicability of analyses using synthetic health data.Scientific reports · 2024Article
- Mimicking clinical trials with synthetic acute myeloid leukemia patients using generative artificial intelligence.NPJ digital medicine · 2024Article
- Synthetic data in radiological imaging: current state and future outlook.BJR artificial intelligence · 2024Review
- Synthetic Tabular Data Evaluation in the Health Domain Covering Resemblance, Utility, and Privacy Dimensions.Methods of information in medicine · 2023Article
- Utility Metrics for Evaluating Synthetic Health Data Generation Methods: Validation Study.JMIR medical informatics · 2022Article
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Authors and funding
2 authors.
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Abstract
AI-based data synthesis has seen rapid progress over the last several years and is increasingly recognized for its promise to enable privacy-respecting high-fidelity data sharing. This is reflected by the growing availability of both commercial and open-sourced software solutions for synthesizing private data. However, despite these recent advances, adequately evaluating the quality of generated synthetic datasets is still an open challenge. We aim to close this gap and introduce a novel holdout-based empirical assessment framework for quantifying the fidelity as well as the privacy risk of synthetic data solutions for mixed-type tabular data. Measuring fidelity is based on statistical distances of lower-dimensional marginal distributions, which provide a model-free and easy-to-communicate empirical metric for the representativeness of a synthetic dataset. Privacy risk is assessed by calculating the individual-level distances to closest record with respect to the training data. By showing that the synthetic samples are just as close to the training as to the holdout data, we yield strong evidence that the synthesizer indeed learned to generalize patterns and is independent of individual training records. We empirically demonstrate the presented framework for seven distinct synthetic data solutions across four mixed-type datasets and compare these then to traditional data perturbation techniques. Both a Python-based implementation of the proposed metrics and the demonstration study setup is made available open-source. The results highlight the need to systematically assess the fidelity just as well as the privacy of these emerging class of synthetic data generators.
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