Evidence map›Paper›PMID 34268464›Full record

ArticleResearch and practice in thrombosis and haemostasis2021

Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting.

Nihal Bakeer, Saunya Dover, Paul Babyn, Brian M Feldman, Annette von Drygalski, Andrea S Doria, Danial M Ignas, Audrey Abad, Cindy Bailey, Ian Beggs and 24 more

Open access · goldAbstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

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  9. Gene therapy for hemophilia: looking beyond factor expression.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 11 countries.

Nihal BakeerIndiana Hemophilia & Thrombosis Center Indianapolis IN USA.ORCID https://orcid.org/0000-0002-3370-8166
Saunya DoverChild Health Evaluative Sciences, Research Institute The Hospital for Sick Children Toronto ON Canada.ORCID https://orcid.org/0000-0001-5935-8101
Paul BabynDepartment of Medical Imaging University of Saskatchewan and Saskatchewan Health Authority Saskatoon City Hospital SK Canada.
Brian M FeldmanChild Health Evaluative Sciences, Research Institute The Hospital for Sick Children Toronto ON Canada.ORCID https://orcid.org/0000-0002-7813-9665
Annette von DrygalskiDivision of Hematology/Oncology University of California San Diego San Diego CA USA.ORCID https://orcid.org/0000-0002-9426-6322
Andrea S DoriaDepartment of Medical Imaging University of Toronto The Hospital for Sick Children Toronto ON Canada.
Danial M IgnasChild Health Evaluative Sciences, Research Institute The Hospital for Sick Children Toronto ON Canada.
Audrey AbadChild Health Evaluative Sciences, Research Institute The Hospital for Sick Children Toronto ON Canada.
Cindy BaileyLos Angeles Orthopaedic Treatment Centre Los Angeles CA USA.
Ian BeggsDepartment of Radiology Royal Infirmary of Edinburgh NHS Lothian Edinburgh UK.
Eric Y ChangUniversity of California San Diego Medical Center San Diego CA USA.
Amy DunnDivision of Pediatric Hematology, Oncology & Marrow Transplant Department of Pediatrics Nationwide Children's Hospital The Ohio State University College of Medicine Columbus OH USA.
Sharon FunkHemophilia and Thrombosis Center University of Colorado Anschutz Medical Campus Aurora CO USA.
Sridhar GibikoteDivision of Clinical Radiology Christian Medical College Vellore India.
Nicholas GoddardKatherine Dormandy Haemophilia Centre Royal Free Hospital London UK.
Pamela HilliardChild Health Evaluative Sciences, Research Institute The Hospital for Sick Children Toronto ON Canada.
Shyamkumar N KeshavaDivision of Clinical Radiology Christian Medical College Vellore India.ORCID https://orcid.org/0000-0002-4290-496X
Rebecca Kruse-JarresUniversity of Washington and Washington Center for Bleeding Disorders Seattle WA USA.
Yingjia LiUltrasound Department Manfang Hospital Guangzhou China.
Sébastien LobetHaemostasis and Thrombosis Unit Division of Haematology Cliniques Universitaires Saint-Luc Brussels Belgium.
Marilyn Manco-JohnsonHemophilia & Thrombosis Center Department of Pediatrics University of Colorado Anschutz Medical Center Aurora CO USA.
Carlo MartinoliDepartment of Health Sciences (DISSAL) Università di Genova IRCCS Ospedale Policlinico San Martino Genova Italy.
James S O'DonnellIrish Centre for Vascular Biology Royal College of Surgeons in Ireland Dublin Ireland.
Olympia PapakonstantinouAttikon General Hospital National and Kapodistrian University of Athens Athens Greece.
Helen PergantouPediatric Hemophilia Centre/Haemostatis and Thrombosis Unit Aghia Sophia Children's Hospital Athens Greece.
Pradeep PoonnooseDepartment of Orthopedics Unit 2 Christian Medical College Vellore India.
Felipe QuerolHaemostasis and Thrombosis Unit Hospital LA FE Universidad de Valencia Valencia Spain.
Alok SrivastavaDepartment of Hematology Christian Medical College Vellore India.
Bruno SteinerDepartment of Rehabilitation Medicine Physical Therapy and MSKUS Program Washington Center for Bleeding Disorders University of Washington Seattle WA USA.
Karen StrikeSchool of Rehabilitation Science Faculty of Health Science Hamilton Niagara Regional Hemophilia Program Hamilton Health Sciences McMaster University Hamilton ON Canada.
Merel Timmervan Creveldkliniek University Medical Center Utrecht Utrecht The Netherlands.
Pascal N TyrrellDepartment of Medical Imaging Institute of Medical Science Toronto ON Canada.
Logi VidarssonDiagnostic Imaging The Hospital for Sick Children Toronto ON Canada.
Victor S BlanchetteDepartment of Pediatrics Division of Hematology/Oncology University of Toronto The Hospital for Sick Children Toronto ON Canada.ORCID https://orcid.org/0000-0003-3341-5010
Hospital for Sick Children · CAChristian Medical College, Vellore · INUniversity of Toronto · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Washington · USChildren's Hospital Agia Sophia · GRCliniques Universitaires Saint-Luc · BEIndiana Hemophilia and Thrombosis Center · USNanfang Hospital · CNNational and Kapodistrian University of Athens · GRNationwide Children's Hospital · USNHS Lothian · GBOrthopaedic Hospital · USOspedale Policlinico San Martino · ITRegional Municipality of Niagara · CARoyal College of Surgeons in Ireland · IESaskatchewan Health Authority · CAThe Royal Free Hospital · GBUniversitat de València · ESUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFor persons with hemophilia, optimization of joint outcomes is an important unmet need. The aim of this initiative was to determine use of ultrasound in evaluating arthropathy in persons with hemophilia, and to move toward consensus among hemophilia care providers regarding the preferred ultrasound protocols for global adaptation.

methodsA global survey of hemophilia treatment centers was conducted that focused on understanding how and why ultrasound was being used and endeavored to move toward consensus definitions of both point-of-care musculoskeletal ultrasound (POC-MSKUS) and full diagnostic ultrasound, terminology to describe structures being assessed by ultrasound, and how these assessments should be interpreted. Next, an in-person meeting of an international group of hemophilia health care professionals and patient representatives was held, with the objective of achieving consensus regarding the acquisition and interpretation of POC-MSKUS and full diagnostic ultrasound for use in the assessment of musculoskeletal (MSK) pathologies in persons with hemophilia.

resultsThe recommendations were that clear definitions of the types of ultrasound examinations should be adopted and that a standardized ultrasound scoring/measurement system should be developed, tested, and implemented. The scoring/measurement system should be tiered to allow for a range of complexity yet maintain the ability for comparison across levels.

conclusionUltrasound is an evolving technology increasingly used for the assessment of MSK outcomes in persons with hemophilia. As adoption increases globally for clinical care and research, it will become increasingly important to establish clear guidelines for image acquisition, interpretation, and reporting to ensure accuracy, consistency, and comparability across groups.

Indexed as

consensushemophiliamusculoskeletalsurveysultrasonography

Identifiers

PMID34268464
PMCPMC8271584
OpenAlexW3181447431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.