ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 47 citations in OpenAlex.
- LEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts and its Protective Role against Dementia.Medicine and science in sports and exercise · 2026Observational
- Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Midlife sensory and motor measures among best predictors in parsimonious models of long-term cognitive decline and incidence of cognitive impairment in aging adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms and Impact of Cognitive Reserve in Normal Aging and Alzheimer's Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Association among cardiorespiratory fitness, plasma biomarkers of pathology and astrocyte reactivity, and cognition in autosomal-dominant Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.Medicine and science in sports and exercise · 2025Article
- Physical activity andmedRxiv : the preprint server for health sciences · 2025Article
- Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cardiorespiratory fitness does not predict longitudinal changes in manual dexterity, cognition or corticospinal excitability in multiple sclerosis.Frontiers in aging neuroscience · 2025Article
- Sex modifies the association between cardiorespiratory fitness and insulin resistance in adults at risk for Alzheimer's disease.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2025Observational
- Distinct medical and substance use histories associate with cognitive decline in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2024Article
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Relations Between Cardiorespiratory Fitness and Cognition in Older Adults With Amnestic Mild Cognitive Impairment From the Aerobic Exercise and Cognitive Training (ACT) Trial: Sex Differences.Archives of rehabilitation research and clinical translation · 2024Article
- The Role of Physical Activity in Adjunctive Nursing Management of Neuro-Degenerative Diseases among Older Adults: A Systematic Review of Interventional Studies.Life (Basel, Switzerland) · 2024Review
- Relationship Between Excessive Daytime Sleepiness and Caudate Nucleus Volume in Patients with Subjective Cognitive Decline: A Study from the SILCODE Using the Volbrain.Journal of Alzheimer's disease reports · 2024Article
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionCardiorespiratory fitness (CRF) may mitigate Alzheimer's disease (AD) progression. This study examined the longitudinal associations of CRF with brain atrophy and cognitive decline in a late-middle-aged cohort of adults at risk for AD.
methodsOne hundred ten cognitively unimpaired adults (66% female, mean age at baseline 64.2 ± 5.7 years) completed a baseline graded treadmill exercise test, two brain magnetic resonance imaging scans (over 4.67 ± 1.17 years), and two to three cognitive assessments (over 3.26 ± 1.02 years). Linear mixed effects models examined the longitudinal associations adjusted for covariates.
resultsParticipants with higher baseline CRF had slower annual decline in total gray matter volume ( DISCUSSION: CRF is a modifiable physiological attribute that may be targeted during the preclinical phase of AD in effort to delay disease progression, perhaps most effectively among those with genetic risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.